Abstract
Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution and provides insight into fundamental aspects of human adaptive immunity and pathogenesis of infection.
Original language | English |
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Title of host publication | Antibody Fc |
Subtitle of host publication | Linking Adaptive and Innate Immunity |
Publisher | Elsevier |
Chapter | 18 |
Pages | 317-332 |
Number of pages | 16 |
ISBN (Print) | 9780123948021 |
DOIs | |
Publication status | Published - 2013 Sept 1 |
Subject classification (UKÄ)
- Microbiology in the medical area
- Infectious Medicine
- Immunology in the medical area
Free keywords
- Glycan hydrolysis
- Glycosylation
- Immune evasion
- Immunoglobulin
- Immunoglobulin binding
- Proteases