Bacterial vaginosis - a microbiological and immunological enigma

U Forsum, Elisabet Holst, P G Larsson, Alejandra Vasquez, T Jakobsson, I Mattsby-Baltzer

Research output: Contribution to journalReview articlepeer-review


The development of bacterial vaginosis (BV) among women of childbearing age and the resulting quantitative and qualitative shift from normally occurring lactobacilli in the vagina to a mixture of mainly anaerobic bacteria is a microbiological and immunological enigma that so far has precluded the formulation of a unifying generally accepted theory on the aetiology and clinical course of BV This critical review highlights some of the more important aspects of BV research that could help in formulating new basic ideas respecting the biology of BV not least the importance of the interleukin mediators of local inflammatory responses and the bacterial shift from the normally occurring lactobacilli species: L. crispatus, L. gasseri, L. jensenii, and L. iners to a mixed flora dominated by anaerobic bacteria.
Original languageEnglish
Pages (from-to)81-90
JournalAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Issue number2
Publication statusPublished - 2005

Subject classification (UKÄ)

  • Microbiology in the medical area

Free keywords

  • immune response
  • taxonomy
  • lactobacilli
  • bacterial vaginosis
  • ecology
  • nugent scoring


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