Bark of passiflora edulis treatment stimulates antioxidant capacity, and reduces dyslipidemia and body fat in db/db mice

Marielle Fernanda Panelli, Damiana Tortolero Pierine, Sérgio Luiz Borges de Souza, Artur Júnio Togneri Ferron, Jéssica Leite Garcia, Klinsmann Carolo Dos Santos, Matheus Antônio Filiol Belin, Giuseppina Pace Pereira Lima, Milena Galhardo Borguini, Igor Otávio Minatel, Antônio Carlos Cicogna, Fabiane Valentini Francisqueti, Camila Renata Corrêa

Research output: Contribution to journalArticlepeer-review

18 Citations (SciVal)


Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and polyamines in pulp, leaves, seeds, and bark. Aim: To evaluate the effect of bark of Passiflora edulis (BPe) on body composition, and metabolic and oxidative stress parameters in genetically obese mice. Methods: Obese male db/db mice (n = 14 animals) received normal feeds and water ad libitum for 8 weeks. Then, animals were randomly divided to continue either receiving standard chow (obese, n = 7 (OB)) or feed with standard chow plus bark Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 8 more weeks, totaling 16 weeks. BPe was added to chow (7 g of BPe/kg of chow corresponding to 1.5 g/kg of body weight). The parameters evaluated in animals included food and caloric intake, body weight, body fat, plasma glucose, triglycerides, and total cholesterol. Malondialdehyde and antioxidant capacity were evaluated in plasma and organs. Groups were compared by Student t-test, with p < 0.05. Results: BPe reduced visceral and subcutaneous fat deposit and adiposity index, cholesterol and triglyceride levels, ameliorated the antioxidant capacity, and reduced malondialdehyde (MDA) levels. Conclusion: the bark of Passiflora edulis was effective in improving body composition, and metabolic and antioxidant parameters in obese mice.

Original languageEnglish
Article number120
Issue number9
Publication statusPublished - 2018 Sep 8
Externally publishedYes

Subject classification (UKÄ)

  • Endocrinology and Diabetes


  • Db/db mice
  • Obesity
  • Oxidative stress
  • Passiflora edulis


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