Basal metabolic rate and the evolution of the adaptive immune system

Lars Råberg, Mikael Vestberg, Dennis Hasselquist, Rikard Holmdahl, Erik Svensson, Jan-Åke Nilsson

Research output: Contribution to journalArticlepeer-review

82 Citations (SciVal)

Abstract

Vertebrates have evolved an adaptive immune system in addition to the ancestral innate immune system. It is often assumed that a trade-off between costs and benefits of defence governs the evolution of immunological defence, but the costs and benefits specific to the adaptive immune system are poorly known. We used genetically engineered mice lacking lymphocytes (i.e. mice without adaptive, but with innate, immunity) as a model of the ancestral state in the evolution of the vertebrate immune system. To investigate if the magnitude of adaptive defence is constrained by the energetic costs of producing lymphocytes etc., we compared the basal metabolic rate of normal and lymphocyte-deficient mice. We found that lymphocyte-deficient mice had a higher basal metabolic rate than normal mice with both innate and adaptive immune defence. This suggests that the evolution of the adaptive immune system has not been constrained by energetic costs. Rather, it should have been favoured by the energy savings associated with a combination of innate and adaptive immune defence.
Original languageEnglish
Pages (from-to)817-821
JournalRoyal Society of London. Proceedings B. Biological Sciences
Volume269
Issue number1493
DOIs
Publication statusPublished - 2002

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Evolutionary Ecology (432112238), Medical Inflammation Research (013212019), MEMEG (432112240)

Subject classification (UKÄ)

  • Immunology in the medical area

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