Benzylidene protected bis-MPA: A convenient dendrimer building block

Ulf Annby; Mats Malmberg; Bo Pettersson; Nicola Rehnberg

doi:10.1016/S0040-4039(98)00395-5

Benzylidene protected bis-MPA: A convenient dendrimer building block

Ulf Annby, Mats Malmberg, Bo Pettersson, Nicola Rehnberg

Research output: Contribution to journal › Article › peer-review

Abstract

Benzylidene protected bis-MPA, 2,2-bis(hydroxymethyl)propanoic acid, was synthesised and evaluated as building block in the construction of dendrimers. It was found that the anhydride of benzylidene protected bis-MPA reacts with neopentylic alcohols to give high yields of acylated products. Purification is facilitated by the crystalline nature of most ester products. Deprotection by hydrogenolysis gives polyol dendrimers in good yields.

Original language	English
Pages (from-to)	3217-3220
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4039(98)00395-5
Publication status	Published - 1998 May 14
Externally published	Yes

Subject classification (UKÄ)

Organic Chemistry

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10.1016/S0040-4039(98)00395-5

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title = "Benzylidene protected bis-MPA: A convenient dendrimer building block",

abstract = "Benzylidene protected bis-MPA, 2,2-bis(hydroxymethyl)propanoic acid, was synthesised and evaluated as building block in the construction of dendrimers. It was found that the anhydride of benzylidene protected bis-MPA reacts with neopentylic alcohols to give high yields of acylated products. Purification is facilitated by the crystalline nature of most ester products. Deprotection by hydrogenolysis gives polyol dendrimers in good yields.",

author = "Ulf Annby and Mats Malmberg and Bo Pettersson and Nicola Rehnberg",

year = "1998",

month = may,

day = "14",

doi = "10.1016/S0040-4039(98)00395-5",

language = "English",

volume = "39",

pages = "3217--3220",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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number = "20",

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T1 - Benzylidene protected bis-MPA

T2 - A convenient dendrimer building block

AU - Annby, Ulf

AU - Malmberg, Mats

AU - Pettersson, Bo

AU - Rehnberg, Nicola

PY - 1998/5/14

Y1 - 1998/5/14

N2 - Benzylidene protected bis-MPA, 2,2-bis(hydroxymethyl)propanoic acid, was synthesised and evaluated as building block in the construction of dendrimers. It was found that the anhydride of benzylidene protected bis-MPA reacts with neopentylic alcohols to give high yields of acylated products. Purification is facilitated by the crystalline nature of most ester products. Deprotection by hydrogenolysis gives polyol dendrimers in good yields.

AB - Benzylidene protected bis-MPA, 2,2-bis(hydroxymethyl)propanoic acid, was synthesised and evaluated as building block in the construction of dendrimers. It was found that the anhydride of benzylidene protected bis-MPA reacts with neopentylic alcohols to give high yields of acylated products. Purification is facilitated by the crystalline nature of most ester products. Deprotection by hydrogenolysis gives polyol dendrimers in good yields.

U2 - 10.1016/S0040-4039(98)00395-5

DO - 10.1016/S0040-4039(98)00395-5

M3 - Article

AN - SCOPUS:0032516380

SN - 0040-4039

VL - 39

SP - 3217

EP - 3220

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 20

ER -

Benzylidene protected bis-MPA: A convenient dendrimer building block

Abstract

Subject classification (UKÄ)

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