Bioactive alkenylphenols from Piper obliquum.

Carola Valdivia; Nieves Marquez; John Eriksson; Antonio Vilaseca; Eduardo Muñoz; Olov Sterner

doi:10.1016/j.bmc.2008.01.018

Bioactive alkenylphenols from Piper obliquum.

Carola Valdivia, Nieves Marquez, John Eriksson, Antonio Vilaseca, Eduardo Muñoz, Olov Sterner

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

Original language	English
Pages (from-to)	4120-4126
Journal	Bioorganic & Medicinal Chemistry
Volume	16
Issue number	7
DOIs	https://doi.org/10.1016/j.bmc.2008.01.018
Publication status	Published - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Applied Microbiology (LTH) (011001021), Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Organic Chemistry
Industrial Biotechnology

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10.1016/j.bmc.2008.01.018

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@article{5505df31494e4283a6108bb19715417d,

title = "Bioactive alkenylphenols from Piper obliquum.",

abstract = "Various parts of Piper obliquum Ru{\'i}z & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.",

author = "Carola Valdivia and Nieves Marquez and John Eriksson and Antonio Vilaseca and Eduardo Mu{\~n}oz and Olov Sterner",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Microbiology (LTH) (011001021), Organic chemistry (S/LTH) (011001240)",

year = "2008",

doi = "10.1016/j.bmc.2008.01.018",

language = "English",

volume = "16",

pages = "4120--4126",

journal = "Bioorganic & Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Bioactive alkenylphenols from Piper obliquum.

AU - Valdivia, Carola

AU - Marquez, Nieves

AU - Eriksson, John

AU - Vilaseca, Antonio

AU - Muñoz, Eduardo

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Microbiology (LTH) (011001021), Organic chemistry (S/LTH) (011001240)

PY - 2008

Y1 - 2008

N2 - Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

AB - Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

U2 - 10.1016/j.bmc.2008.01.018

DO - 10.1016/j.bmc.2008.01.018

M3 - Article

SN - 0968-0896

VL - 16

SP - 4120

EP - 4126

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

IS - 7

ER -

Bioactive alkenylphenols from Piper obliquum.

Abstract

Bibliographical note

Subject classification (UKÄ)

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