BIOACTIVE SECONDARY METABOLITES -Isolation Characterization and Synthesis

Carola Valdivia

BIOACTIVE SECONDARY METABOLITES -Isolation Characterization and Synthesis

Carola Valdivia

Centre for Analysis and Synthesis

Research output: Thesis › Doctoral Thesis (compilation)

Abstract

Nature produces biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay-guided fractionations were applied to several plants as well as to a basidiomycete. Our studies resulted in the purification and characterization of a diverse range of compounds displaying activity in a variety of biological assays. New secondary metabolites and semi-synthetic compounds were obtained from Bolivian species Piper heterophyllum, Piper obliquum, Piper longestylosum and Baccharis genistelloides, from the European species Myrtus communis, Thapsia garganica and from the basidiomycete Coprinus heptemerus.

Original language	English
Qualification	Doctor
Awarding Institution	Centre for Analysis and Synthesis
Supervisors/Advisors	Sterner, Olov, Supervisor
Award date	2006 Aug 18
Publisher	Organic Chemistry, Lund University
ISBN (Print)	91-628-6881-0
Publication status	Published - 2006

Bibliographical note

Defence details

Date: 2006-08-18
Time: 09:30
Place: Kemicentrum, sal K:G, Lunds Tekniska Högskola

External reviewer(s)

Name: Björk, Lars
Title: Professor
Affiliation: Institutionen för evolution, genomik och systematik, Systematisk botanik

---

<div class="article_info">Giovanni Appendino, Lucia Maxia, Piergiorgio Bettoni, Monica Locatelli, Carola Valdivia, Mauro Ballero, Michael Stavri, Simon Gibbons and Olov Sterner. <span class="article_issue_date">2006</span>. <span class="article_title">Antibacterial Galloylated Alkylphloroglucinol Glucides from Myrtle (Myrtus communis)</span> <span class="journal_series_title">Journal of Natural products</span>, <span class="journal_volume">vol 69</span> <span class="journal_pages">pp 67-70</span>. <span class="journal_distributor">Media-Tryck</span></div>
<div class="article_info">Giovanni Appendino, Simona Prosperini, Carola Valdivia, Mauro Ballero, Giampiero Colombano, Richard Billington, Armando Genazzani and Olov Sterner. <span class="article_issue_date">2005</span>. <span class="article_title">SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their possible biogenesis</span> <span class="journal_series_title">Journal of natural products</span>, <span class="journal_volume">vol 68</span> <span class="journal_pages">pp 71-75</span>. <span class="journal_distributor">Media-Tryck</span></div>
<div class="article_info">. <span class="article_issue_date">2005</span>. <span class="article_title">SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their Possible Biogenesis</span> <span class="journal_series_title">Journal of Natural Products</span>, <span class="journal_volume">vol 68</span> <span class="journal_pages">pp 71-75</span>. <span class="journal_distributor">Media-Tryck</span></div>
<div class="article_info">Carola Valdivia. <span class="article_issue_date">2005</span>. <span class="article_title">Diterpenoid from Coprinus heptemerus</span> <span class="journal_series_title">Tetrahedron</span>, <span class="journal_pages">pp 77-82</span>. <span class="journal_distributor">Media-Tryck</span></div>
<div class="article_info">Carola Valdivia, Patricia Mollinedo, Antonio Vilaseca and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Prenylated protocatechuic acid derivatives with antioxidant activity from Piper heterophyllum</span> (manuscript)</div>
<div class="article_info">Carola Valdivia, John Eriksson, Antonio Vilaseca and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Alkenylphenols and a new 4-chromanone derivative from Piper obliquum</span> (manuscript)</div>
<div class="article_info">Carola Valdivia, Antonio Vilaseca and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Benzoic acid derivatives from piper longestylosum</span> (manuscript)</div>
<div class="article_info">Carola Valdivia, Åke Boketof, Björn Olde, Christer Owman, Antonio Vilaseca, Lenny Fuentes and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Activation of the free fatty acid receptor GPR40 by (+)-curcuphenol and related synthetic compounds</span> (manuscript)</div>

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Organic Chemistry

Free keywords

Organisk kemi
Organic chemistry
Baccharis genistelloides
Piper heterophyllum
Myrtus Communis
Coprinus heptemerus
Thapsia garganica
Piper longestylosum
Piper obliquum
Natural Products

Cite this

@phdthesis{87a8e48497334aeb95e8750b916c0765,

title = "BIOACTIVE SECONDARY METABOLITES -Isolation Characterization and Synthesis",

abstract = "Nature produces biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay-guided fractionations were applied to several plants as well as to a basidiomycete. Our studies resulted in the purification and characterization of a diverse range of compounds displaying activity in a variety of biological assays. New secondary metabolites and semi-synthetic compounds were obtained from Bolivian species Piper heterophyllum, Piper obliquum, Piper longestylosum and Baccharis genistelloides, from the European species Myrtus communis, Thapsia garganica and from the basidiomycete Coprinus heptemerus.",

keywords = "Organisk kemi, Organic chemistry, Baccharis genistelloides, Piper heterophyllum, Myrtus Communis, Coprinus heptemerus, Thapsia garganica, Piper longestylosum, Piper obliquum, Natural Products",

author = "Carola Valdivia",

note = "Defence details Date: 2006-08-18 Time: 09:30 Place: Kemicentrum, sal K:G, Lunds Tekniska H{\"o}gskola External reviewer(s) Name: Bj{\"o}rk, Lars Title: Professor Affiliation: Institutionen f{\"o}r evolution, genomik och systematik, Systematisk botanik --- <div class={"}article_info{"}>Giovanni Appendino, Lucia Maxia, Piergiorgio Bettoni, Monica Locatelli, Carola Valdivia, Mauro Ballero, Michael Stavri, Simon Gibbons and Olov Sterner. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>Antibacterial Galloylated Alkylphloroglucinol Glucides from Myrtle (Myrtus communis)</span> <span class={"}journal_series_title{"}>Journal of Natural products</span>, <span class={"}journal_volume{"}>vol 69</span> <span class={"}journal_pages{"}>pp 67-70</span>. <span class={"}journal_distributor{"}>Media-Tryck</span></div> <div class={"}article_info{"}>Giovanni Appendino, Simona Prosperini, Carola Valdivia, Mauro Ballero, Giampiero Colombano, Richard Billington, Armando Genazzani and Olov Sterner. <span class={"}article_issue_date{"}>2005</span>. <span class={"}article_title{"}>SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their possible biogenesis</span> <span class={"}journal_series_title{"}>Journal of natural products</span>, <span class={"}journal_volume{"}>vol 68</span> <span class={"}journal_pages{"}>pp 71-75</span>. <span class={"}journal_distributor{"}>Media-Tryck</span></div> <div class={"}article_info{"}>. <span class={"}article_issue_date{"}>2005</span>. <span class={"}article_title{"}>SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their Possible Biogenesis</span> <span class={"}journal_series_title{"}>Journal of Natural Products</span>, <span class={"}journal_volume{"}>vol 68</span> <span class={"}journal_pages{"}>pp 71-75</span>. <span class={"}journal_distributor{"}>Media-Tryck</span></div> <div class={"}article_info{"}>Carola Valdivia. <span class={"}article_issue_date{"}>2005</span>. <span class={"}article_title{"}>Diterpenoid from Coprinus heptemerus</span> <span class={"}journal_series_title{"}>Tetrahedron</span>, <span class={"}journal_pages{"}>pp 77-82</span>. <span class={"}journal_distributor{"}>Media-Tryck</span></div> <div class={"}article_info{"}>Carola Valdivia, Patricia Mollinedo, Antonio Vilaseca and Olov Sterner. <span class={"}article_issue_date{"}></span>. <span class={"}article_title{"}>Prenylated protocatechuic acid derivatives with antioxidant activity from Piper heterophyllum</span> (manuscript)</div> <div class={"}article_info{"}>Carola Valdivia, John Eriksson, Antonio Vilaseca and Olov Sterner. <span class={"}article_issue_date{"}></span>. <span class={"}article_title{"}>Alkenylphenols and a new 4-chromanone derivative from Piper obliquum</span> (manuscript)</div> <div class={"}article_info{"}>Carola Valdivia, Antonio Vilaseca and Olov Sterner. <span class={"}article_issue_date{"}></span>. <span class={"}article_title{"}>Benzoic acid derivatives from piper longestylosum</span> (manuscript)</div> <div class={"}article_info{"}>Carola Valdivia, {\AA}ke Boketof, Bj{\"o}rn Olde, Christer Owman, Antonio Vilaseca, Lenny Fuentes and Olov Sterner. <span class={"}article_issue_date{"}></span>. <span class={"}article_title{"}>Activation of the free fatty acid receptor GPR40 by (+)-curcuphenol and related synthetic compounds</span> (manuscript)</div> The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",

year = "2006",

language = "English",

isbn = "91-628-6881-0",

publisher = "Organic Chemistry, Lund University",

type = "Doctoral Thesis (compilation)",

school = "Centre for Analysis and Synthesis",

}

TY - THES

T1 - BIOACTIVE SECONDARY METABOLITES -Isolation Characterization and Synthesis

AU - Valdivia, Carola

N1 - Defence details Date: 2006-08-18 Time: 09:30 Place: Kemicentrum, sal K:G, Lunds Tekniska Högskola External reviewer(s) Name: Björk, Lars Title: Professor Affiliation: Institutionen för evolution, genomik och systematik, Systematisk botanik --- <div class="article_info">Giovanni Appendino, Lucia Maxia, Piergiorgio Bettoni, Monica Locatelli, Carola Valdivia, Mauro Ballero, Michael Stavri, Simon Gibbons and Olov Sterner. <span class="article_issue_date">2006</span>. <span class="article_title">Antibacterial Galloylated Alkylphloroglucinol Glucides from Myrtle (Myrtus communis)</span> <span class="journal_series_title">Journal of Natural products</span>, <span class="journal_volume">vol 69</span> <span class="journal_pages">pp 67-70</span>. <span class="journal_distributor">Media-Tryck</span></div> <div class="article_info">Giovanni Appendino, Simona Prosperini, Carola Valdivia, Mauro Ballero, Giampiero Colombano, Richard Billington, Armando Genazzani and Olov Sterner. <span class="article_issue_date">2005</span>. <span class="article_title">SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their possible biogenesis</span> <span class="journal_series_title">Journal of natural products</span>, <span class="journal_volume">vol 68</span> <span class="journal_pages">pp 71-75</span>. <span class="journal_distributor">Media-Tryck</span></div> <div class="article_info">. <span class="article_issue_date">2005</span>. <span class="article_title">SERCA-Inhibiting Activity of C-19 Terpenolides from Thapsia garganica and their Possible Biogenesis</span> <span class="journal_series_title">Journal of Natural Products</span>, <span class="journal_volume">vol 68</span> <span class="journal_pages">pp 71-75</span>. <span class="journal_distributor">Media-Tryck</span></div> <div class="article_info">Carola Valdivia. <span class="article_issue_date">2005</span>. <span class="article_title">Diterpenoid from Coprinus heptemerus</span> <span class="journal_series_title">Tetrahedron</span>, <span class="journal_pages">pp 77-82</span>. <span class="journal_distributor">Media-Tryck</span></div> <div class="article_info">Carola Valdivia, Patricia Mollinedo, Antonio Vilaseca and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Prenylated protocatechuic acid derivatives with antioxidant activity from Piper heterophyllum</span> (manuscript)</div> <div class="article_info">Carola Valdivia, John Eriksson, Antonio Vilaseca and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Alkenylphenols and a new 4-chromanone derivative from Piper obliquum</span> (manuscript)</div> <div class="article_info">Carola Valdivia, Antonio Vilaseca and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Benzoic acid derivatives from piper longestylosum</span> (manuscript)</div> <div class="article_info">Carola Valdivia, Åke Boketof, Björn Olde, Christer Owman, Antonio Vilaseca, Lenny Fuentes and Olov Sterner. <span class="article_issue_date"></span>. <span class="article_title">Activation of the free fatty acid receptor GPR40 by (+)-curcuphenol and related synthetic compounds</span> (manuscript)</div> The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2006

Y1 - 2006

N2 - Nature produces biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay-guided fractionations were applied to several plants as well as to a basidiomycete. Our studies resulted in the purification and characterization of a diverse range of compounds displaying activity in a variety of biological assays. New secondary metabolites and semi-synthetic compounds were obtained from Bolivian species Piper heterophyllum, Piper obliquum, Piper longestylosum and Baccharis genistelloides, from the European species Myrtus communis, Thapsia garganica and from the basidiomycete Coprinus heptemerus.

AB - Nature produces biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay-guided fractionations were applied to several plants as well as to a basidiomycete. Our studies resulted in the purification and characterization of a diverse range of compounds displaying activity in a variety of biological assays. New secondary metabolites and semi-synthetic compounds were obtained from Bolivian species Piper heterophyllum, Piper obliquum, Piper longestylosum and Baccharis genistelloides, from the European species Myrtus communis, Thapsia garganica and from the basidiomycete Coprinus heptemerus.

KW - Organisk kemi

KW - Organic chemistry

KW - Baccharis genistelloides

KW - Piper heterophyllum

KW - Myrtus Communis

KW - Coprinus heptemerus

KW - Thapsia garganica

KW - Piper longestylosum

KW - Piper obliquum

KW - Natural Products

M3 - Doctoral Thesis (compilation)

SN - 91-628-6881-0

PB - Organic Chemistry, Lund University

ER -

BIOACTIVE SECONDARY METABOLITES -Isolation Characterization and Synthesis

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

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Cite this