Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

Carlos R. Arza; Xiaoya Li; Sedef İlk; Yang Liu; Deniz Demircan; Baozhong Zhang

doi:10.1039/d2tb01233b

Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

Carlos R. Arza, Xiaoya Li, Sedef İlk, Yang Liu, Deniz Demircan, Baozhong Zhang

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.

Original language	English
Pages (from-to)	8064-8074
Number of pages	11
Journal	Journal of Materials Chemistry B
Volume	10
Issue number	39
DOIs	https://doi.org/10.1039/d2tb01233b
Publication status	Published - 2022 Sept 9

Subject classification (UKÄ)

Polymer Chemistry

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10.1039/d2tb01233bLicence: CC BY

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title = "Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units",

abstract = "This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.",

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T1 - Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

AU - Arza, Carlos R.

AU - Li, Xiaoya

AU - İlk, Sedef

AU - Liu, Yang

AU - Demircan, Deniz

AU - Zhang, Baozhong

PY - 2022/9/9

Y1 - 2022/9/9

N2 - This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.

AB - This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.

U2 - 10.1039/d2tb01233b

DO - 10.1039/d2tb01233b

M3 - Article

C2 - 36111601

AN - SCOPUS:85139804114

SN - 2050-7518

VL - 10

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EP - 8074

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 39

ER -

Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

Abstract

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