BioMAX the first macromolecular crystallography beamline at MAX IV Laboratory

Thomas Ursby, Karl Åhnberg, Roberto Appio, Oskar Aurelius, Artur Barczyk, Antonio Bartalesi, Monika Bjelcic, Fredrik Bolmsten, Yngve Cerenius, R. Bruce Doak, Mikel Eguiraun, Thomas Eriksson, Ross J. Friel, Ishkhan Gorgisyan, Andrea Gross, Vahid Haghighat, Franz Hennies, Elmir Jagudin, Brian Norsk Jensen, Tobias JeppssonMarco Kloos, Julio Lidon-Simon, Gustavo M.A.De Lima, Robert Lizatovic, Magnus Lundin, Antonio Milan-Otero, Mirko Milas, Jie Nan, Alberto Nardella, Anders Rosborg, Anastasiia Shilova, Robert L. Shoeman, Frank Siewert, Peter Sondhauss, Vladimir O. Talibov, Hamed Tarawneh, Johan Thånell, Marjolein Thunnissen, Johan Unge, Christopher Ward, Ana Gonzaleza, Uwe Muellera

Research output: Contribution to journalArticlepeer-review

4 Citations (SciVal)

Abstract

BioMAX is the first macromolecular crystallography beamline at the MAX IV Laboratory 3 GeV storage ring, which is the first operational multi-bend achromat storage ring. Due to the low-emittance storage ring, BioMAX has a parallel, high-intensity X-ray beam, even when focused down to 20 μm × 5 μm using the bendable focusing mirrors. The beam is tunable in the energy range 5-25 keV using the in-vacuum undulator and the horizontally deflecting double-crystal monochromator. BioMAX is equipped with an MD3 diffractometer, an ISARA high-capacity sample changer and an EIGER 16M hybrid pixel detector. Data collection at BioMAX is controlled using the newly developed MXCuBE3 graphical user interface, and sample tracking is handled by ISPyB. The computing infrastructure includes data storage and processing both at MAX IV and the Lund University supercomputing center LUNARC. With state-of-the-art instrumentation, a high degree of automation, a user-friendly control system interface and remote operation, BioMAX provides an excellent facility for most macromolecular crystallography experiments. Serial crystallography using either a high-viscosity extruder injector or the MD3 as a fixed-target scanner is already implemented. The serial crystallography activities at MAX IV Laboratory will be further developed at the microfocus beamline MicroMAX, when it comes into operation in 2022. MicroMAX will have a 1 μm × 1 μm beam focus and a flux up to 1015 photons s with main applications in serial crystallography, room-temperature structure determinations and time-resolved experiments.

Original languageEnglish
Pages (from-to)1415-1429
Number of pages15
JournalJournal of Synchrotron Radiation
Volume27
DOIs
Publication statusPublished - 2020 Sep 1

Subject classification (UKÄ)

  • Atom and Molecular Physics and Optics

Keywords

  • automation
  • beamline
  • macromolecular crystallography
  • MBA
  • micro-focus
  • remote operation
  • serial crystallography

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