Abstract
Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30(+) lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell differentiation did not preclude expression of CD3 epsilon, generally assumed to be a T-cell associated antigen.
| Original language | English |
|---|---|
| Pages (from-to) | 159-165 |
| Journal | European Journal of Haematology |
| Volume | 79 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2007 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Division of Hematology and Transfusion Medicine (013041100), Pathology, (Lund) (013030000), Oncology, MV (013035000)
Subject classification (UKÄ)
- Hematology
Free keywords
- PAX5
- biphenotypic
- lymphoma
- bigenotypic