Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke

Giuseppe Santopolo, Jens P. Magnusson, Olle Lindvall, Zaal Kokaia, Jonas Frisén

Research output: Contribution to journalArticlepeer-review

9 Citations (SciVal)

Abstract

Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.

Original languageEnglish
Article number1732
JournalCells
Volume9
Issue number7
DOIs
Publication statusPublished - 2020

Subject classification (UKÄ)

  • Neurosciences
  • Cell and Molecular Biology

Keywords

  • astrocyte
  • neurogenesis
  • stem cell
  • striatum
  • stroke

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