Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: results from SCAPIS

Göran Bergström; Annika Rosengren; Elin Bacsovics Brolin; John Brandberg; Kerstin Cederlund; Gunnar Engström; Jan E Engvall; Maria J Eriksson; Isabel Gonçalves; Emil Hagström; Stefan K. James; Tomas Jernberg; Mikael Lilja; Martin Magnusson; Anders Persson; Margaretha Persson; Anette Sandström; Caroline Schmidt; Linn Skoglund Larsson; Johan Sundström; Eva Swahn; Stefan Söderberg; Kjell Torén; Carl Johan Östgren; Erik Lampa; Lars Lind

doi:10.1016/j.atherosclerosis.2023.01.024

Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: results from SCAPIS

Göran Bergström, Annika Rosengren, Elin Bacsovics Brolin, John Brandberg, Kerstin Cederlund, Gunnar Engström, Jan E Engvall, Maria J Eriksson, Isabel Gonçalves, Emil Hagström, Stefan K. James, Tomas Jernberg, Mikael Lilja, Martin Magnusson, Anders Persson, Margaretha Persson, Anette Sandström, Caroline Schmidt, Linn Skoglund Larsson, Johan SundströmEva Swahn, Stefan Söderberg, Kjell Torén, Carl Johan Östgren, Erik Lampa, Lars Lind

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aims
Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.
Methods
We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).
Results
The probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p Conclusions
Similar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.

Original language	English
Pages (from-to)	46-54
Number of pages	23
Journal	Atherosclerosis
Volume	373
Early online date	2023 Feb 1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2023.01.024
Publication status	Published - 2023

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems
Public Health, Global Health, Social Medicine and Epidemiology

Free keywords

Weight
Weight gain
Midlife
Coronary artery calcium score
Sex

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2023.01.024Licence: CC BY

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Bergström, G., Rosengren, A., Bacsovics Brolin, E., Brandberg, J., Cederlund, K., Engström, G., Engvall, J. E., Eriksson, M. J., Gonçalves, I., Hagström, E., James, S. K., Jernberg, T., Lilja, M., Magnusson, M., Persson, A., Persson, M., Sandström, A., Schmidt, C., Skoglund Larsson, L., ... Lind, L. (2023). Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: results from SCAPIS. Atherosclerosis, 373, 46-54. https://doi.org/10.1016/j.atherosclerosis.2023.01.024

@article{153c7635453d4ceda7f42aee9e4ef9a5,

title = "Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: results from SCAPIS",

abstract = "Background and aimsElevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.MethodsWe used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).ResultsThe probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p ConclusionsSimilar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.",

keywords = "Weight, Weight gain, Midlife, Coronary artery calcium score, Sex",

author = "G{\"o}ran Bergstr{\"o}m and Annika Rosengren and {Bacsovics Brolin}, Elin and John Brandberg and Kerstin Cederlund and Gunnar Engstr{\"o}m and Engvall, {Jan E} and Eriksson, {Maria J} and Isabel Gon{\c c}alves and Emil Hagstr{\"o}m and James, {Stefan K.} and Tomas Jernberg and Mikael Lilja and Martin Magnusson and Anders Persson and Margaretha Persson and Anette Sandstr{\"o}m and Caroline Schmidt and {Skoglund Larsson}, Linn and Johan Sundstr{\"o}m and Eva Swahn and Stefan S{\"o}derberg and Kjell Tor{\'e}n and {\"O}stgren, {Carl Johan} and Erik Lampa and Lars Lind",

year = "2023",

doi = "10.1016/j.atherosclerosis.2023.01.024",

language = "English",

volume = "373",

pages = "46--54",

journal = "Atherosclerosis",

issn = "1879-1484",

publisher = "Elsevier",

}

Bergström, G, Rosengren, A, Bacsovics Brolin, E, Brandberg, J, Cederlund, K, Engström, G, Engvall, JE, Eriksson, MJ, Gonçalves, I, Hagström, E, James, SK, Jernberg, T, Lilja, M, Magnusson, M, Persson, A, Persson, M, Sandström, A, Schmidt, C, Skoglund Larsson, L, Sundström, J, Swahn, E, Söderberg, S, Torén, K, Östgren, CJ, Lampa, E & Lind, L 2023, 'Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: results from SCAPIS', Atherosclerosis, vol. 373, pp. 46-54. https://doi.org/10.1016/j.atherosclerosis.2023.01.024

TY - JOUR

T1 - Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis

T2 - results from SCAPIS

AU - Bergström, Göran

AU - Rosengren, Annika

AU - Bacsovics Brolin, Elin

AU - Brandberg, John

AU - Cederlund, Kerstin

AU - Engström, Gunnar

AU - Engvall, Jan E

AU - Eriksson, Maria J

AU - Gonçalves, Isabel

AU - Hagström, Emil

AU - James, Stefan K.

AU - Jernberg, Tomas

AU - Lilja, Mikael

AU - Magnusson, Martin

AU - Persson, Anders

AU - Persson, Margaretha

AU - Sandström, Anette

AU - Schmidt, Caroline

AU - Skoglund Larsson, Linn

AU - Sundström, Johan

AU - Swahn, Eva

AU - Söderberg, Stefan

AU - Torén, Kjell

AU - Östgren, Carl Johan

AU - Lampa, Erik

AU - Lind, Lars

PY - 2023

Y1 - 2023

N2 - Background and aimsElevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.MethodsWe used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).ResultsThe probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p ConclusionsSimilar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.

AB - Background and aimsElevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.MethodsWe used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).ResultsThe probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p ConclusionsSimilar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.

KW - Weight

KW - Weight gain

KW - Midlife

KW - Coronary artery calcium score

KW - Sex

U2 - 10.1016/j.atherosclerosis.2023.01.024

DO - 10.1016/j.atherosclerosis.2023.01.024

M3 - Article

C2 - 36813601

SN - 1879-1484

VL - 373

SP - 46

EP - 54

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: results from SCAPIS

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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