Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel

Alexander Ivanov; Lars Nilsson; Igor Galaev; Bo Mattiasson

doi:10.1016/j.ijpharm.2008.02.017

Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel

Alexander Ivanov, Lars Nilsson, Igor Galaev, Bo Mattiasson

Research output: Contribution to journal › Article › peer-review

Abstract

Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.

Original language	English
Pages (from-to)	36-43
Journal	International Journal of Pharmaceutics
Volume	358
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2008.02.017
Publication status	Published - 2008

Subject classification (UKÄ)

Industrial Biotechnology
Other Engineering and Technologies

Free keywords

Mucoadhesive
Drug delivery
Boronic acid
Controlled release
Smart material

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10.1016/j.ijpharm.2008.02.017

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title = "Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel",

abstract = "Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.",

keywords = "Mucoadhesive, Drug delivery, Boronic acid, Controlled release, Smart material",

author = "Alexander Ivanov and Lars Nilsson and Igor Galaev and Bo Mattiasson",

year = "2008",

doi = "10.1016/j.ijpharm.2008.02.017",

language = "English",

volume = "358",

pages = "36--43",

journal = "International Journal of Pharmaceutics",

issn = "1873-3476",

publisher = "Elsevier",

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T1 - Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel

AU - Ivanov, Alexander

AU - Nilsson, Lars

AU - Galaev, Igor

AU - Mattiasson, Bo

PY - 2008

Y1 - 2008

N2 - Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.

AB - Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.

KW - Mucoadhesive

KW - Drug delivery

KW - Boronic acid

KW - Controlled release

KW - Smart material

U2 - 10.1016/j.ijpharm.2008.02.017

DO - 10.1016/j.ijpharm.2008.02.017

M3 - Article

C2 - 18394833

SN - 1873-3476

VL - 358

SP - 36

EP - 43

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel

Abstract

Subject classification (UKÄ)

Free keywords

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