Brain irradiation: effects on normal brain parenchyma and radiation injury.

Pia Sundgren, Yue Cao

Research output: Contribution to journalArticlepeer-review

48 Citations (SciVal)


Radiation therapy is a major treatment modality for malignant and benign brain tumors. Concerns of radiation effects on the brain tissue and neurocognitive function and quality of life increase as survival of patients treated for brain tumors improves. In this article, the clinical and neurobehavioral symptoms and signs of radiation-induced brain injury, possible histopathology, and the potential of functional, metabolic, and molecular imaging as a biomarker for assessment and prediction of neurotoxicity after brain irradiation and imaging findings in radiation necrosis are discussed.
Original languageEnglish
Pages (from-to)657
JournalNeuroimaging Clinics of North America
Issue number4
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Radiology, Nuclear Medicine and Medical Imaging
  • Urology and Nephrology


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