Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas

BERTIL JOHANSSON; FREDRIK MERTENS; SVERRE HEIM; ULF KRISTOFFERSSON; NILS MANDAHL; HAKAN OLSSON; FELIX MITELMAN

doi:10.1111/j.1601-5223.1988.tb00193.x

Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas

BERTIL JOHANSSON, FREDRIK MERTENS, SVERRE HEIM, ULF KRISTOFFERSSON, NILS MANDAHL, HAKAN OLSSON, FELIX MITELMAN

Skåne University Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.

Original language	English
Pages (from-to)	131-137
Journal	Hereditas
Volume	109
Issue number	1
DOIs	https://doi.org/10.1111/j.1601-5223.1988.tb00193.x
Publication status	Published - 1988 Jan 1

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1601-5223.1988.tb00193.x

Cite this

JOHANSSON, BERTIL., MERTENS, FREDRIK., HEIM, SVERRE., KRISTOFFERSSON, ULF., MANDAHL, NILS., OLSSON, HAKAN., & MITELMAN, FELIX. (1988). Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas. Hereditas, 109(1), 131-137. https://doi.org/10.1111/j.1601-5223.1988.tb00193.x

@article{1386705e775a44a0945b85da0b7d77fd,

title = "Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas",

abstract = "The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.",

author = "BERTIL JOHANSSON and FREDRIK MERTENS and SVERRE HEIM and ULF KRISTOFFERSSON and NILS MANDAHL and HAKAN OLSSON and FELIX MITELMAN",

year = "1988",

month = jan,

day = "1",

doi = "10.1111/j.1601-5223.1988.tb00193.x",

language = "English",

volume = "109",

pages = "131--137",

journal = "Hereditas",

issn = "0018-0661",

publisher = "Wiley-Blackwell",

number = "1",

}

JOHANSSON, BERTIL , MERTENS, FREDRIK, HEIM, SVERRE, KRISTOFFERSSON, ULF , MANDAHL, NILS, OLSSON, HAKAN & MITELMAN, FELIX 1988, 'Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas', Hereditas, vol. 109, no. 1, pp. 131-137. https://doi.org/10.1111/j.1601-5223.1988.tb00193.x

TY - JOUR

T1 - Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas

AU - JOHANSSON, BERTIL

AU - MERTENS, FREDRIK

AU - HEIM, SVERRE

AU - KRISTOFFERSSON, ULF

AU - MANDAHL, NILS

AU - OLSSON, HAKAN

AU - MITELMAN, FELIX

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.

AB - The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.

UR - http://www.scopus.com/inward/record.url?scp=0023778419&partnerID=8YFLogxK

U2 - 10.1111/j.1601-5223.1988.tb00193.x

DO - 10.1111/j.1601-5223.1988.tb00193.x

M3 - Article

C2 - 3192422

AN - SCOPUS:0023778419

SN - 0018-0661

VL - 109

SP - 131

EP - 137

JO - Hereditas

JF - Hereditas

IS - 1

ER -

Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this