TY - JOUR
T1 - Breast percent density
T2 - Estimation on digital mammograms and central tomosynthesis projections
AU - Bakic, Predrag R.
AU - Carton, Ann Katherine
AU - Kontos, Despina
AU - Zhang, Cuiping
AU - Troxel, Andrea B.
AU - Maidment, Andrew D.A.
PY - 2009/7
Y1 - 2009/7
N2 - Purpose: To evaluate inter- and intrareader agreement in breast percent density (PD) estimation on clinical digital mammograms and central digital breast tomosynthesis (DBT) projection images. Materials and Methods: This HIPAA-compliant study had institutional review board approval; all patients provided informed consent. Breast PD estimation was performed on the basis of anonymized digital mammograms and central DBT projections in 39 women (mean age, 51 years; range, 31-80 years). All women had recently detected abnormalities or biopsyproved cancers. PD was estimated by three experienced readers on the mediolateral oblique views of the contralateral breasts by using software; each reader repeated the estimation after 2 months. Spearman correlations of interand intrareader and intermodality PD estimates, as well as κ statistics between categoric PD estimates, were computed. Results: High correlation (ρ = 0.91) was observed between PD estimates on digital mammograms and those on central DBT projections, averaged over all estimations; the corresponding κ coefficient (0.79) indicated substantial agreement. Mean interreader agreement for PD estimation on central DBT projections (ρ = 0.85 ± 0.05 [standard deviation]) was significantly higher (P < .01) than that for PD estimation on digital mammograms (ρ = 0.75 ± 0.05); the corresponding κ coefficients indicated substantial (κ = 0.65 ± 0.12) and moderate (κ = 0.55 ± 0.14) agreement for central DBT projections and digital mammograms, respectively. Conclusion: High correlation between PD estimates on digital mammograms and those on central DBT projections suggests the latter could be used until a method for PD estimation based on three-dimensional reconstructed images is introduced. Moreover, clinical PD estimation is possible with reduced radiation dose, as each DBT projection was acquired by using about 22% of the dose for a single mammographic projection.
AB - Purpose: To evaluate inter- and intrareader agreement in breast percent density (PD) estimation on clinical digital mammograms and central digital breast tomosynthesis (DBT) projection images. Materials and Methods: This HIPAA-compliant study had institutional review board approval; all patients provided informed consent. Breast PD estimation was performed on the basis of anonymized digital mammograms and central DBT projections in 39 women (mean age, 51 years; range, 31-80 years). All women had recently detected abnormalities or biopsyproved cancers. PD was estimated by three experienced readers on the mediolateral oblique views of the contralateral breasts by using software; each reader repeated the estimation after 2 months. Spearman correlations of interand intrareader and intermodality PD estimates, as well as κ statistics between categoric PD estimates, were computed. Results: High correlation (ρ = 0.91) was observed between PD estimates on digital mammograms and those on central DBT projections, averaged over all estimations; the corresponding κ coefficient (0.79) indicated substantial agreement. Mean interreader agreement for PD estimation on central DBT projections (ρ = 0.85 ± 0.05 [standard deviation]) was significantly higher (P < .01) than that for PD estimation on digital mammograms (ρ = 0.75 ± 0.05); the corresponding κ coefficients indicated substantial (κ = 0.65 ± 0.12) and moderate (κ = 0.55 ± 0.14) agreement for central DBT projections and digital mammograms, respectively. Conclusion: High correlation between PD estimates on digital mammograms and those on central DBT projections suggests the latter could be used until a method for PD estimation based on three-dimensional reconstructed images is introduced. Moreover, clinical PD estimation is possible with reduced radiation dose, as each DBT projection was acquired by using about 22% of the dose for a single mammographic projection.
UR - http://www.scopus.com/inward/record.url?scp=67650097301&partnerID=8YFLogxK
U2 - 10.1148/radiol.2521081621
DO - 10.1148/radiol.2521081621
M3 - Article
C2 - 19420321
AN - SCOPUS:67650097301
SN - 0033-8419
VL - 252
SP - 40
EP - 49
JO - Radiology
JF - Radiology
IS - 1
ER -