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Abstract
Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (<100 mg/L) and a high CRP group (>100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in the whole sepsis group and 0.85 vs. 0.59, P = .003 in the culture-positive subgroup). The CRP levels also correlated with ICU and hospital LOS in survivors (P < .001 and P = .002), again independent of SAPS-3. Conclusion: An admission CRP level >100 mg/L is associated with an increased risk of ICU and 30-day mortality as well as prolonged LOS in survivors, irrespective of morbidity measured with SAPS-3. Thus, CRP may be a simple, early marker for prognosis in ICU admissions for sepsis.
Original language | English |
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Pages (from-to) | 73-79 |
Number of pages | 7 |
Journal | Journal of Critical Care |
Volume | 56 |
DOIs | |
Publication status | Published - 2020 |
Subject classification (UKÄ)
- Anesthesiology and Intensive Care
Free keywords
- C-reactive protein
- Critical care
- Intensive care
- Mortality
- Prediction
- Sepsis
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Dive into the research topics of 'C-reactive protein as a prognostic factor in intensive care admissions for sepsis: A Swedish multicenter study'. Together they form a unique fingerprint.Projects
- 1 Active
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SweCrit, a critical care biobank
Frigyesi, A., Friberg, H., Levin, H., Spångfors, M., Lundberg, O., Annborn, M., Boström, L., Didriksson, I. K. L., Lengquist, M., Johnsson, P., Koozi, H. & Thorgeirsdóttir, B.
2015/01/01 → 2027/12/31
Project: Research