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Abstract
Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (<100 mg/L) and a high CRP group (>100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in the whole sepsis group and 0.85 vs. 0.59, P = .003 in the culture-positive subgroup). The CRP levels also correlated with ICU and hospital LOS in survivors (P < .001 and P = .002), again independent of SAPS-3. Conclusion: An admission CRP level >100 mg/L is associated with an increased risk of ICU and 30-day mortality as well as prolonged LOS in survivors, irrespective of morbidity measured with SAPS-3. Thus, CRP may be a simple, early marker for prognosis in ICU admissions for sepsis.
Original language | English |
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Pages (from-to) | 73-79 |
Number of pages | 7 |
Journal | Journal of Critical Care |
Volume | 56 |
DOIs | |
Publication status | Published - 2020 |
Subject classification (UKÄ)
- Anesthesiology and Intensive Care
Free keywords
- C-reactive protein
- Critical care
- Intensive care
- Mortality
- Prediction
- Sepsis
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Dive into the research topics of 'C-reactive protein as a prognostic factor in intensive care admissions for sepsis: A Swedish multicenter study'. Together they form a unique fingerprint.Projects
- 1 Active
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SweCrit, a critical care biobank
Frigyesi, A. (PI), Friberg, H. (PI), Levin, H. (PI), Spångfors, M. (Researcher), Lundberg, O. (Researcher), Annborn, M. (Researcher), Boström, L. (Research student), Didriksson, I. K. L. (Research student), Lengquist, M. (Research student), Johnsson, P. (Research student), Koozi, H. (Research student) & Thorgeirsdóttir, B. (Research student)
2015/01/01 → 2027/12/31
Project: Research