C-reactive protein levels following standard neurosurgical procedures

Johan Bengzon, Anders Grubb, A Bune, K Hellström, Veronica Lindström, Lennart Brandt

Research output: Contribution to journalArticlepeer-review

17 Citations (SciVal)


Background. The aim of the present study was to establish the magnitude and time-course of C-reactive protein increases following routine neurosurgical procedures in the absence of clinical and laboratory signs of infection. Method. C-reactive protein levels were studied daily following ventriculo-peritoneal shunt implantation, anterior cervical fusion, vestibular schwannoma operation, supratentorial glioma surgery, endovascular intracranial aneurysm treatment and open cerebral aneurysm surgery. Findings. The magnitude of the C-reactive protein increase depended on the extent of surgical trauma and peak-levels were recorded between postoperative day one and four after which the levels tapered off. Interpretation. Increases occur-ring after the fourth postoperative day are likely to be caused by complications of surgery, e.g. infection.
Original languageEnglish
Pages (from-to)667-671
JournalActa Neurochirurgica
Issue number8
Publication statusPublished - 2003

Subject classification (UKÄ)

  • Surgery
  • Medicinal Chemistry
  • Neurology
  • Pharmacology and Toxicology


  • C-reactive protein
  • postoperative
  • neurosurgery


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