Can a single dose response predict the effect of montelukast on exercise-induced bronchoconstriction?

Elin T G Kersten; Anne M Akkerman-Nijland; Jean M M Driessen; Zuzana Diamant; Bernard J Thio

doi:10.1002/ppul.23324

Can a single dose response predict the effect of montelukast on exercise-induced bronchoconstriction?

Elin T G Kersten, Anne M Akkerman-Nijland, Jean M M Driessen, Zuzana Diamant, Bernard J Thio

Respiratory Medicine, Allergology, and Palliative Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Exercise-induced bronchoconstriction (EIB) can be prevented by a single dose of montelukast (MLK). The effect is variable, similar to the variable responsiveness observed after daily treatment with MLK. We hypothesized that the effect of a single MLK-dose (5 or 10 mg) on EIB could predict the clinical effectiveness of longer term once daily treatment.

Original language	English
Journal	Pediatric Pulmonology
Early online date	2015 Oct 22
DOIs	https://doi.org/10.1002/ppul.23324
Publication status	Published - 2015

Subject classification (UKÄ)

Respiratory Medicine and Allergy

Access to Document

10.1002/ppul.23324

http://www.ncbi.nlm.nih.gov/pubmed/26492292?dopt=Abstract

Cite this

@article{47dcea737cbb4d63ac6698d4ddba84e7,

title = "Can a single dose response predict the effect of montelukast on exercise-induced bronchoconstriction?",

abstract = "Exercise-induced bronchoconstriction (EIB) can be prevented by a single dose of montelukast (MLK). The effect is variable, similar to the variable responsiveness observed after daily treatment with MLK. We hypothesized that the effect of a single MLK-dose (5 or 10 mg) on EIB could predict the clinical effectiveness of longer term once daily treatment.",

author = "Kersten, {Elin T G} and Akkerman-Nijland, {Anne M} and Driessen, {Jean M M} and Zuzana Diamant and Thio, {Bernard J}",

year = "2015",

doi = "10.1002/ppul.23324",

language = "English",

journal = "Pediatric Pulmonology",