Cancer and Risk of COVID-19 Through a General Community Survey

Karla A. Lee; Wenjie Ma; Daniel R. Sikavi; David A. Drew; Long H. Nguyen; Ruth C.E. Bowyer; M. Jorge Cardoso; Tove Fall; Maxim B. Freidin; Maria Gomez; Mark Graham; Chuan Guo Guo; Amit D. Joshi; Sohee Kwon; Chun Han Lo; Mary Ni Lochlainn; Cristina Menni; Benjamin Murray; Raaj Mehta; Mingyang Song; Carole H. Sudre; Veronique Bataille; Thomas Varsavsky; Alessia Visconti; Paul W. Franks; Jonathan Wolf; Claire J. Steves; Sebastien Ourselin; Tim D. Spector; Andrew T. Chan

doi:10.1634/theoncologist.2020-0572

Cancer and Risk of COVID-19 Through a General Community Survey

Karla A. Lee, Wenjie Ma, Daniel R. Sikavi, David A. Drew, Long H. Nguyen, Ruth C.E. Bowyer, M. Jorge Cardoso, Tove Fall, Maxim B. Freidin, Maria Gomez, Mark Graham, Chuan Guo Guo, Amit D. Joshi, Sohee Kwon, Chun Han Lo, Mary Ni Lochlainn, Cristina Menni, Benjamin Murray, Raaj Mehta, Mingyang SongCarole H. Sudre, Veronique Bataille, Thomas Varsavsky, Alessia Visconti, Paul W. Franks, Jonathan Wolf, Claire J. Steves, Sebastien Ourselin, Tim D. Spector, Andrew T. Chan

Research output: Contribution to journal › Article › peer-review

Abstract

Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.

Original language	English
Journal	The Oncologist
Volume	26
Issue number	1
DOIs	https://doi.org/10.1634/theoncologist.2020-0572
Publication status	Published - 2021

Subject classification (UKÄ)

Cancer and Oncology
Public Health, Global Health, Social Medicine and Epidemiology

Free keywords

Covid-19
SARS-CoV-2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1634/theoncologist.2020-0572

COVID Symptom Study Sweden
Franks, P. (PI), Gomez, M. F. (Researcher) & Björk, J. (Researcher)
2020/04/20 → …
Project: Research

Cite this

Lee, K. A., Ma, W., Sikavi, D. R., Drew, D. A., Nguyen, L. H., Bowyer, R. C. E., Cardoso, M. J., Fall, T., Freidin, M. B., Gomez, M., Graham, M., Guo, C. G., Joshi, A. D., Kwon, S., Lo, C. H., Lochlainn, M. N., Menni, C., Murray, B., Mehta, R., ... Chan, A. T. (2021). Cancer and Risk of COVID-19 Through a General Community Survey. The Oncologist, 26(1). https://doi.org/10.1634/theoncologist.2020-0572

@article{75a74cbf6ebf4e1f8e6c7a44a482e278,

title = "Cancer and Risk of COVID-19 Through a General Community Survey",

abstract = "Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.",

keywords = "Covid-19, SARS-CoV-2",

author = "Lee, {Karla A.} and Wenjie Ma and Sikavi, {Daniel R.} and Drew, {David A.} and Nguyen, {Long H.} and Bowyer, {Ruth C.E.} and Cardoso, {M. Jorge} and Tove Fall and Freidin, {Maxim B.} and Maria Gomez and Mark Graham and Guo, {Chuan Guo} and Joshi, {Amit D.} and Sohee Kwon and Lo, {Chun Han} and Lochlainn, {Mary Ni} and Cristina Menni and Benjamin Murray and Raaj Mehta and Mingyang Song and Sudre, {Carole H.} and Veronique Bataille and Thomas Varsavsky and Alessia Visconti and Franks, {Paul W.} and Jonathan Wolf and Steves, {Claire J.} and Sebastien Ourselin and Spector, {Tim D.} and Chan, {Andrew T.}",

year = "2021",

doi = "10.1634/theoncologist.2020-0572",

language = "English",

volume = "26",

journal = "The Oncologist",

issn = "1083-7159",

publisher = "AlphaMed Press",

number = "1",

}

Lee, KA, Ma, W, Sikavi, DR, Drew, DA, Nguyen, LH, Bowyer, RCE, Cardoso, MJ, Fall, T, Freidin, MB, Gomez, M, Graham, M, Guo, CG, Joshi, AD, Kwon, S, Lo, CH, Lochlainn, MN, Menni, C, Murray, B, Mehta, R, Song, M, Sudre, CH, Bataille, V, Varsavsky, T, Visconti, A, Franks, PW, Wolf, J, Steves, CJ, Ourselin, S, Spector, TD & Chan, AT 2021, 'Cancer and Risk of COVID-19 Through a General Community Survey', The Oncologist, vol. 26, no. 1. https://doi.org/10.1634/theoncologist.2020-0572

TY - JOUR

T1 - Cancer and Risk of COVID-19 Through a General Community Survey

AU - Lee, Karla A.

AU - Ma, Wenjie

AU - Sikavi, Daniel R.

AU - Drew, David A.

AU - Nguyen, Long H.

AU - Bowyer, Ruth C.E.

AU - Cardoso, M. Jorge

AU - Fall, Tove

AU - Freidin, Maxim B.

AU - Gomez, Maria

AU - Graham, Mark

AU - Guo, Chuan Guo

AU - Joshi, Amit D.

AU - Kwon, Sohee

AU - Lo, Chun Han

AU - Lochlainn, Mary Ni

AU - Menni, Cristina

AU - Murray, Benjamin

AU - Mehta, Raaj

AU - Song, Mingyang

AU - Sudre, Carole H.

AU - Bataille, Veronique

AU - Varsavsky, Thomas

AU - Visconti, Alessia

AU - Franks, Paul W.

AU - Wolf, Jonathan

AU - Steves, Claire J.

AU - Ourselin, Sebastien

AU - Spector, Tim D.

AU - Chan, Andrew T.

PY - 2021

Y1 - 2021

N2 - Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.

AB - Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.

KW - Covid-19

KW - SARS-CoV-2

U2 - 10.1634/theoncologist.2020-0572

DO - 10.1634/theoncologist.2020-0572

M3 - Article

C2 - 32845538

AN - SCOPUS:85090316468

SN - 1083-7159

VL - 26

JO - The Oncologist

JF - The Oncologist

IS - 1

ER -

Cancer and Risk of COVID-19 Through a General Community Survey

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Fingerprint

Projects

COVID Symptom Study Sweden

Cite this