Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study

Yahia Al-Jebari; Ingrid Glimelius; C Berglund Nord; Olof Ståhl; Torgrim Tandstad; Allan Jensen; Hege Sagstuen Haugnes; Gedske Daugaard; Lars Rylander; Aleksander Giwercman

doi:10.1371/journal.pmed.1002816

Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study

Yahia Al-Jebari, Ingrid Glimelius, C Berglund Nord, Olof Ståhl, Torgrim Tandstad, Allan Jensen, Hege Sagstuen Haugnes, Gedske Daugaard, Lars Rylander, Aleksander Giwercman

Research output: Contribution to journal › Article › peer-review

Abstract

Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.

Original language	English
Article number	e1002816
Journal	PLoS Medicine
Volume	16
Issue number	6
DOIs	https://doi.org/10.1371/journal.pmed.1002816
Publication status	Published - 2019

Subject classification (UKÄ)

Cancer and Oncology
Pediatrics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pmed.1002816

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002816

1 Doctoral Thesis (compilation)

The health of the children in relation to paternal age, cancer, and medication
Al-Jebari, Y., 2021, Lund: Lund University, Faculty of Medicine. 81 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
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Al-Jebari, Y., Glimelius, I., Berglund Nord, C., Ståhl, O., Tandstad, T., Jensen, A., Haugnes, H. S., Daugaard, G., Rylander, L., & Giwercman, A. (2019). Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study. PLoS Medicine, 16(6), Article e1002816. https://doi.org/10.1371/journal.pmed.1002816

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title = "Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study",

abstract = "Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.",

author = "Yahia Al-Jebari and Ingrid Glimelius and {Berglund Nord}, C and Olof St{\aa}hl and Torgrim Tandstad and Allan Jensen and Haugnes, {Hege Sagstuen} and Gedske Daugaard and Lars Rylander and Aleksander Giwercman",

year = "2019",

doi = "10.1371/journal.pmed.1002816",

language = "English",

volume = "16",

journal = "PLoS Medicine",

issn = "1549-1676",

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Al-Jebari, Y, Glimelius, I, Berglund Nord, C, Ståhl, O, Tandstad, T, Jensen, A, Haugnes, HS, Daugaard, G, Rylander, L & Giwercman, A 2019, 'Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study', PLoS Medicine, vol. 16, no. 6, e1002816. https://doi.org/10.1371/journal.pmed.1002816

TY - JOUR

T1 - Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study

AU - Al-Jebari, Yahia

AU - Glimelius, Ingrid

AU - Berglund Nord, C

AU - Ståhl, Olof

AU - Tandstad, Torgrim

AU - Jensen, Allan

AU - Haugnes, Hege Sagstuen

AU - Daugaard, Gedske

AU - Rylander, Lars

AU - Giwercman, Aleksander

PY - 2019

Y1 - 2019

N2 - Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.

AB - Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.

U2 - 10.1371/journal.pmed.1002816

DO - 10.1371/journal.pmed.1002816

M3 - Article

C2 - 31163029

SN - 1549-1676

VL - 16

JO - PLoS Medicine

JF - PLoS Medicine

IS - 6

M1 - e1002816

ER -

Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

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Research output

The health of the children in relation to paternal age, cancer, and medication

Cite this