Capacitive biosensors for ultra-sensitive assays

Bo Mattiasson, Martin Hedström

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Capacitive binding assays have long been considered highly sensitive. The underlying method in such assays includes sending short potential pulses and then registering the current. However, with the introduction of current pulses and registration of potential responses, the stability improved significantly, leading to assays of extreme sensitivities. The new assaying technology has been applied in a range of affinity binding assays, from immunoassays via DNA base pairing to the use of molecularly imprinted polymers (MIPs). Overall, very good sensitivities have been recorded, and the MIPs exhibit high stability and reusability.

    Original languageEnglish
    Pages (from-to)233-238
    Number of pages6
    JournalTrac. Trends in Analytical Chemistry
    Volume79
    DOIs
    Publication statusPublished - 2016 May 1

    Subject classification (UKÄ)

    • Analytical Chemistry

    Free keywords

    • Affinity biosensor
    • Capacitive transduction
    • Electropolymerization
    • Gold surface
    • Microcontact imprinting
    • MIP
    • Ultra-sensitive

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