Capsaicin enhances allergic contact dermatitis in guinea pig.

Joanna Wallengren, Rolf Ekman, Halvor Möller

Research output: Contribution to journalArticlepeer-review

Abstract

Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously tin the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well us by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either between induction and challenge, or before sensitization, In comparison with controls, the contact dermatitis was Enhanced in both groups of animals treated with capsaicin.
Original languageEnglish
Pages (from-to)30-34
JournalContact Dermatitis
Volume24
Issue number1
DOIs
Publication statusPublished - 1991

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

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