Abstract
Carbohydrate-deficient transferrin (CDT) was measured in three populations using anion-exchange chromatography followed by radioimmunoassay (CDTectTM) and a new high-performance liquid chromatography (HPLC) method. The correlation between the methods in 50 consecutive clinical samples was good (r = 0.87). However, in a set of 49 samples with CDT concentrations close to the reference value of the methods, the correlation was low (r = 0.51). In addition, among controls, no correlation between the methods was found (r = 0.10). Abnormal isoforms of transferrin were noted in 5% of the clinical samples. HPLC determination of CDT offers the advantage of identifying these isoforms of transferrin and thus reducing analytical pitfalls associated with the CDTectTM method.
| Original language | English |
|---|---|
| Pages (from-to) | 397-402 |
| Journal | Alcohol and Alcoholism |
| Volume | 31 |
| Issue number | 4 |
| Publication status | Published - 1996 |
Subject classification (UKÄ)
- Drug Abuse and Addiction
