Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.

Cristiano Fava; Therese Ohlsson; Marketa Sjögren; Angela Tagetti; Peter Almgren; Gunnar Engström; Peter Nilsson; Bo Hedblad; Pietro Minuz; Olle Melander

doi:10.1097/HJH.0000000000000209

Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.

Cristiano Fava, Therese Ohlsson, Marketa Sjögren, Angela Tagetti, Peter Almgren, Gunnar Engström, Peter Nilsson, Bo Hedblad, Pietro Minuz, Olle Melander

Research output: Contribution to journal › Article › peer-review

Abstract

A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.

Original language	English
Pages (from-to)	1424-1428
Journal	Journal of Hypertension
Volume	32
Issue number	7
DOIs	https://doi.org/10.1097/HJH.0000000000000209
Publication status	Published - 2014

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/HJH.0000000000000209

http://www.ncbi.nlm.nih.gov/pubmed/24879493?dopt=Abstract

1 Doctoral Thesis (compilation)

Genetic causes and prediction of hypertension and cardiovascular disease
Ohlsson, T., 2020, Lund: Lund University, Faculty of Medicine. 68 p.
Research output: Thesis › Doctoral Thesis (compilation)

1 Active

Genetic causes and prediction of hypertension
Ohlsson, T. (Researcher)
2014/09/01 → …
Project: Dissertation

Cite this

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title = "Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malm{\"o} Diet and Cancer.",

abstract = "A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.",

author = "Cristiano Fava and Therese Ohlsson and Marketa Sj{\"o}gren and Angela Tagetti and Peter Almgren and Gunnar Engstr{\"o}m and Peter Nilsson and Bo Hedblad and Pietro Minuz and Olle Melander",

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language = "English",

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T1 - Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.

AU - Fava, Cristiano

AU - Ohlsson, Therese

AU - Sjögren, Marketa

AU - Tagetti, Angela

AU - Almgren, Peter

AU - Engström, Gunnar

AU - Nilsson, Peter

AU - Hedblad, Bo

AU - Minuz, Pietro

AU - Melander, Olle

PY - 2014

Y1 - 2014

N2 - A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.

AB - A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.

U2 - 10.1097/HJH.0000000000000209

DO - 10.1097/HJH.0000000000000209

M3 - Article

SN - 1473-5598

VL - 32

SP - 1424

EP - 1428

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 7

ER -

Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Genetic causes and prediction of hypertension and cardiovascular disease

Projects

Genetic causes and prediction of hypertension

Cite this