Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions

Karolin Isaksson; Daniel Åkerberg; Katarzyna Said Hilmersson; Bobby Tingstedt

doi:10.4236/jbise.2011.43028

Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions

Karolin Isaksson, Daniel Åkerberg, Katarzyna Said Hilmersson, Bobby Tingstedt

Surgery (Lund)

Research output: Contribution to specialist publication or newspaper › Specialist publication article › Popular science

Abstract

Two differently charged polypeptides, α-poly-L-lysine and poly-L-glutamate, have previ- ously been shown to effectively reduce postoperative intraabdominal adhesions. Though α-poly-L-lysine showed toxicity in doses too close to the lowest the-rapeutic dose, the aim in the present study was to investigate the possible antiadhesive effect of another four cationic polypeptides.

Original language	English
Pages	200-206
Volume	4
No.	3
Specialist publication	Journal of Biomedical Science and Engineering
Publisher	Scientific Research Publishing (SCIRP)
DOIs	https://doi.org/10.4236/jbise.2011.43028
Publication status	Published - 2011

Subject classification (UKÄ)

Medical and Health Sciences

Free keywords

Postoperative Adhesions
Bioactive Polypeptides
Molecular Structure

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10.4236/jbise.2011.43028

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title = "Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions",

abstract = "Two differently charged polypeptides, α-poly-L-lysine and poly-L-glutamate, have previ- ously been shown to effectively reduce postoperative intraabdominal adhesions. Though α-poly-L-lysine showed toxicity in doses too close to the lowest the-rapeutic dose, the aim in the present study was to investigate the possible antiadhesive effect of another four cationic polypeptides.",

keywords = "Postoperative Adhesions, Bioactive Polypeptides, Molecular Structure",

author = "Karolin Isaksson and Daniel {\AA}kerberg and {Said Hilmersson}, Katarzyna and Bobby Tingstedt",

year = "2011",

doi = "10.4236/jbise.2011.43028",

language = "English",

volume = "4",

pages = "200--206",

journal = "Journal of Biomedical Science and Engineering",

issn = "1937-6871",

publisher = "Scientific Research Publishing (SCIRP)",

}

Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions. / Isaksson, Karolin; Åkerberg, Daniel; Said Hilmersson, Katarzyna et al.
In: Journal of Biomedical Science and Engineering, Vol. 4, No. 3, 2011, p. 200-206.

Research output: Contribution to specialist publication or newspaper › Specialist publication article › Popular science

TY - GEN

T1 - Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions

AU - Isaksson, Karolin

AU - Åkerberg, Daniel

AU - Said Hilmersson, Katarzyna

AU - Tingstedt, Bobby

PY - 2011

Y1 - 2011

N2 - Two differently charged polypeptides, α-poly-L-lysine and poly-L-glutamate, have previ- ously been shown to effectively reduce postoperative intraabdominal adhesions. Though α-poly-L-lysine showed toxicity in doses too close to the lowest the-rapeutic dose, the aim in the present study was to investigate the possible antiadhesive effect of another four cationic polypeptides.

AB - Two differently charged polypeptides, α-poly-L-lysine and poly-L-glutamate, have previ- ously been shown to effectively reduce postoperative intraabdominal adhesions. Though α-poly-L-lysine showed toxicity in doses too close to the lowest the-rapeutic dose, the aim in the present study was to investigate the possible antiadhesive effect of another four cationic polypeptides.

KW - Postoperative Adhesions

KW - Bioactive Polypeptides

KW - Molecular Structure

U2 - 10.4236/jbise.2011.43028

DO - 10.4236/jbise.2011.43028

M3 - Specialist publication article

SN - 1937-6871

VL - 4

SP - 200

EP - 206

JO - Journal of Biomedical Science and Engineering

JF - Journal of Biomedical Science and Engineering

PB - Scientific Research Publishing (SCIRP)

ER -

Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions

Abstract

Subject classification (UKÄ)

Free keywords

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