Cell cycle sibling rivalry Cdc2 vs. Cdk2

Philipp Kaldis, Eiman Aleem

Research output: Contribution to journalReview articlepeer-review


It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G1/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G1/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G1/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that accommodates these novel findings.

Original languageEnglish
Pages (from-to)1491-1494
JournalCell Cycle
Issue number11
Publication statusPublished - 2005 Jan 1
Externally publishedYes

Subject classification (UKÄ)

  • Cell and Molecular Biology


  • Cdc2
  • Cdk2
  • Cyclin E
  • Cyclin-dependent kinase
  • Knockout mice
  • p27


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