Cerebral amyloid angiopathy and cortical microinfarcts as putative substrates of vascular dementia.

Mattias Haglund, Ulla Passant, Martin Sjöbeck, Estifanos Ghebremedhin, Elisabet Englund

Research output: Contribution to journalArticlepeer-review

94 Citations (SciVal)

Abstract

Background and purpose Vascular dementia (VaD) has occasionally been associated with cerebral amyloid angiopathy (CAA), but the prevalence and significance of this counterintuitive relationship are poorly known. Therefore, we investigated the presence and characteristics of CAA in brains of VaD cases. Methods We examined temporal and parietal regions of the cerebral cortex of 26 consecutive VaD cases from the Lund Longitudinal Dementia Study. We carried out immunohistochemistry and routine stainings, determined Apolipoprotein E (ApoE) genotypes, and obtained clinical characteristics on the studied group for retrospective analysis. Results CAA was marked in eight out of 26 cases, and correlated strongly with the presence of cortical microinfarcts, both in the temporal lobe and in the parietal lobe. Based on comparisons with eight age-matched VaD cases without CAA, the clinical records suggested that VaD cases with CAA as a group exhibited less pronounced neurological symptoms. A clear contribution of the ApoE genotype could not be identified. Conclusions Based on a combination of the clinical and pathological data, we suggest that microinfarcts in the cerebral cortex associated with severe CAA may be the primary pathological substrate in a significant proportion of VaD cases. Future studies should be undertaken to confirm or dismiss the hypothesis that these cases exhibit a different symptom profile than VaD cases without CAA. Copyright (c) 2006 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)681-687
JournalInternational Journal of Geriatric Psychiatry
Volume21
Issue number7
DOIs
Publication statusPublished - 2006

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Pathology, (Lund) (013030000)

Subject classification (UKÄ)

  • Psychiatry
  • Geriatrics

Keywords

  • cerebrovascular disorder
  • histopathology
  • neuropathology
  • Alzheimer's disease

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