Cerebral Blood Flow and Cognition. Clinical studies on Dementia and Cognitive Decline.

Arkadiusz Siennicki-Lantz

Cerebral Blood Flow and Cognition. Clinical studies on Dementia and Cognitive Decline.

Research output: Thesis › Doctoral Thesis (compilation)

Abstract

The importance of early detection of brain changes during ageing has been recognised. Single photon emission computed tomography (SPECT) is a method used for estimation of cerebral blood flow (CBF) in clinical work and in research. The aim of thesis was to study CBF in demented and non-demented elderly persons with special reference to blood pressure changes. Elderly women with senile dementia of Alzheimer type (SDAT) showed a decrease of CBF in temporoparietal brain regions and in whole white matter. Non-demented elderly women had abnormalities according to SPECT and assessment with vocabulary and visospatial tests. CBF in white matter was correlated positively with systolic blood pressure in SDAT group. It cannot be ruled out, that alterations in blood pressure in SDAT could have a central origin and be the consequence rather than cause of brain changes. Women with SDAT and orthostatic hypotension had lower CBF in frontal and parieto-frontal regions than SDAT patients who had normal orthostatic blood pressure. Orthostatic hypotension could be a risk factor for a frontal brain damage and exacerbate the dementia disorder. Intra-subject comparison of CBF estimated with two tracers in healthy subject revealed higher perfusion in posterior cortex when using 99mTc ECD compared to 99mTc HMPAO. In contrast, CBF in central areas was seen to be more profuse when using 99mTc HMPAO. These differences should be taken into account in clinical routine. In another study, persons with Age-Associated Memory Impairment but without dementia had restricted CBF in temporal and occipital lobes, in thalamus and in frontal white matter. A longitudinal study of 129 men revealed an association between accumulated vascular disease markers as: carotid stenosis, peripheral arterial stenosis and hypertension at the age of 69 and lower CBF 14 years later. These results indicate that there might be a potential for prophylactic activities to prevent cognitive decline and vascular dementia in non-demented 70-80 year old population

Original language	English
Qualification	Doctor
Awarding Institution
Supervisors/Advisors	[unknown], [unknown], Supervisor, External person
Award date	2000 Mar 2
Publisher	Dr Arkadiusz Siennicki-Lantz, Dept of Community Medicine, Malmö University Hospital, S-205 02 Malmö, Sweden,
ISBN (Print)	91-628-3995-0
Publication status	Published - 2004

Bibliographical note

Defence details

Date: 2000-03-02
Time: 10:15
Place: Lilla Aulan, Medicinsk Forskningscentrum, UMAS, Malmö

External reviewer(s)

Name: Wahlund, Lars-Olof
Title: Docent
Affiliation: [unknown]

---

Article: I. Elmståhl S, Siennicki-Lantz A, Lilja B, Bjunö L. ”A study of Cerebral Blood Flow using 99mTc-HMPAO-SPECT in elderly women with senile dementia of Alzheimer´s type’’ Dementia 1994:5; 302-309

Article: II. Siennicki-Lantz A, Lilja B, Rosén I, Elmståhl S. ”White matter Cerebral Blood Flow andSystolic Blood Pressure in senile dementia of Alzheimer’s type and healthy elderly women’’ Dementia and Geriatric Cognitive Disorders 1998; 9: 29-38

Article: III. Siennicki-Lantz A, Lilja B, Elmståhl S. ”Orthostatic hypotension in Alzheimers’s disease: Result or cause of brain dysfunction?”Aging. Clinical and Experimental Research 1999, 11:155-160

Article: IV. Siennicki-Lantz A, Lilja B, Elmståhl S. ”How to interpret differing Cerebral Blood Flow patterns estimated with 99Tcm-HMPAO and 99Tcm-ECD SPET in a healthy population”Nuclear Medicine Communications 1999; 29: 219-226.

Article: V. Siennicki-Lantz A, Lilja B, Elmståhl S. ”Cerebral Perfusion Deficits in Age-associated Memory Impairment. The Role of Tobacco Smoking” Submitted for publication.

Article: VI. Siennicki-Lantz A, Reinprecht F, Ryding E, Axelsson J, Thorsson O, Elmståhl S. ”CerebralBlood Flow and Vascular Risk Factors in 81-years old men” Manuscript

Subject classification (UKÄ)

Gerontology, specialising in Medical and Health Sciences

Free keywords

Gerontology
Gerontologi
vascular risk factors
carotid ultrasound
peripheral arterial disease
orthostatic hypotension
blood pressure
ageing
SPECT
cerebral blood flow
cognition
Dementia
Alzheimer’s disease

Cite this

@phdthesis{757f092e65ad45b39bdc47089b8ca93a,

title = "Cerebral Blood Flow and Cognition. Clinical studies on Dementia and Cognitive Decline.",

abstract = "The importance of early detection of brain changes during ageing has been recognised. Single photon emission computed tomography (SPECT) is a method used for estimation of cerebral blood flow (CBF) in clinical work and in research. The aim of thesis was to study CBF in demented and non-demented elderly persons with special reference to blood pressure changes. Elderly women with senile dementia of Alzheimer type (SDAT) showed a decrease of CBF in temporoparietal brain regions and in whole white matter. Non-demented elderly women had abnormalities according to SPECT and assessment with vocabulary and visospatial tests. CBF in white matter was correlated positively with systolic blood pressure in SDAT group. It cannot be ruled out, that alterations in blood pressure in SDAT could have a central origin and be the consequence rather than cause of brain changes. Women with SDAT and orthostatic hypotension had lower CBF in frontal and parieto-frontal regions than SDAT patients who had normal orthostatic blood pressure. Orthostatic hypotension could be a risk factor for a frontal brain damage and exacerbate the dementia disorder. Intra-subject comparison of CBF estimated with two tracers in healthy subject revealed higher perfusion in posterior cortex when using 99mTc ECD compared to 99mTc HMPAO. In contrast, CBF in central areas was seen to be more profuse when using 99mTc HMPAO. These differences should be taken into account in clinical routine. In another study, persons with Age-Associated Memory Impairment but without dementia had restricted CBF in temporal and occipital lobes, in thalamus and in frontal white matter. A longitudinal study of 129 men revealed an association between accumulated vascular disease markers as: carotid stenosis, peripheral arterial stenosis and hypertension at the age of 69 and lower CBF 14 years later. These results indicate that there might be a potential for prophylactic activities to prevent cognitive decline and vascular dementia in non-demented 70-80 year old population",

keywords = "Gerontology, Gerontologi, vascular risk factors, carotid ultrasound, peripheral arterial disease, orthostatic hypotension, blood pressure, ageing, SPECT, cerebral blood flow, cognition, Dementia, Alzheimer{\textquoteright}s disease",

author = "Arkadiusz Siennicki-Lantz",

note = "Defence details Date: 2000-03-02 Time: 10:15 Place: Lilla Aulan, Medicinsk Forskningscentrum, UMAS, Malm{\"o} External reviewer(s) Name: Wahlund, Lars-Olof Title: Docent Affiliation: [unknown] --- Article: I. Elmst{\aa}hl S, Siennicki-Lantz A, Lilja B, Bjun{\"o} L. ”A study of Cerebral Blood Flow using 99mTc-HMPAO-SPECT in elderly women with senile dementia of Alzheimer´s type{\textquoteright}{\textquoteright} Dementia 1994:5; 302-309 Article: II. Siennicki-Lantz A, Lilja B, Ros{\'e}n I, Elmst{\aa}hl S. ”White matter Cerebral Blood Flow andSystolic Blood Pressure in senile dementia of Alzheimer{\textquoteright}s type and healthy elderly women{\textquoteright}{\textquoteright} Dementia and Geriatric Cognitive Disorders 1998; 9: 29-38 Article: III. Siennicki-Lantz A, Lilja B, Elmst{\aa}hl S. ”Orthostatic hypotension in Alzheimers{\textquoteright}s disease: Result or cause of brain dysfunction?”Aging. Clinical and Experimental Research 1999, 11:155-160 Article: IV. Siennicki-Lantz A, Lilja B, Elmst{\aa}hl S. ”How to interpret differing Cerebral Blood Flow patterns estimated with 99Tcm-HMPAO and 99Tcm-ECD SPET in a healthy population”Nuclear Medicine Communications 1999; 29: 219-226. Article: V. Siennicki-Lantz A, Lilja B, Elmst{\aa}hl S. ”Cerebral Perfusion Deficits in Age-associated Memory Impairment. The Role of Tobacco Smoking” Submitted for publication. Article: VI. Siennicki-Lantz A, Reinprecht F, Ryding E, Axelsson J, Thorsson O, Elmst{\aa}hl S. ”CerebralBlood Flow and Vascular Risk Factors in 81-years old men” Manuscript",

year = "2004",

language = "English",

isbn = "91-628-3995-0",

publisher = "Dr Arkadiusz Siennicki-Lantz, Dept of Community Medicine, Malm{\"o} University Hospital, S-205 02 Malm{\"o}, Sweden,",

type = "Doctoral Thesis (compilation)",

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TY - THES

T1 - Cerebral Blood Flow and Cognition. Clinical studies on Dementia and Cognitive Decline.

AU - Siennicki-Lantz, Arkadiusz

N1 - Defence details Date: 2000-03-02 Time: 10:15 Place: Lilla Aulan, Medicinsk Forskningscentrum, UMAS, Malmö External reviewer(s) Name: Wahlund, Lars-Olof Title: Docent Affiliation: [unknown] --- Article: I. Elmståhl S, Siennicki-Lantz A, Lilja B, Bjunö L. ”A study of Cerebral Blood Flow using 99mTc-HMPAO-SPECT in elderly women with senile dementia of Alzheimer´s type’’ Dementia 1994:5; 302-309 Article: II. Siennicki-Lantz A, Lilja B, Rosén I, Elmståhl S. ”White matter Cerebral Blood Flow andSystolic Blood Pressure in senile dementia of Alzheimer’s type and healthy elderly women’’ Dementia and Geriatric Cognitive Disorders 1998; 9: 29-38 Article: III. Siennicki-Lantz A, Lilja B, Elmståhl S. ”Orthostatic hypotension in Alzheimers’s disease: Result or cause of brain dysfunction?”Aging. Clinical and Experimental Research 1999, 11:155-160 Article: IV. Siennicki-Lantz A, Lilja B, Elmståhl S. ”How to interpret differing Cerebral Blood Flow patterns estimated with 99Tcm-HMPAO and 99Tcm-ECD SPET in a healthy population”Nuclear Medicine Communications 1999; 29: 219-226. Article: V. Siennicki-Lantz A, Lilja B, Elmståhl S. ”Cerebral Perfusion Deficits in Age-associated Memory Impairment. The Role of Tobacco Smoking” Submitted for publication. Article: VI. Siennicki-Lantz A, Reinprecht F, Ryding E, Axelsson J, Thorsson O, Elmståhl S. ”CerebralBlood Flow and Vascular Risk Factors in 81-years old men” Manuscript

PY - 2004

Y1 - 2004

N2 - The importance of early detection of brain changes during ageing has been recognised. Single photon emission computed tomography (SPECT) is a method used for estimation of cerebral blood flow (CBF) in clinical work and in research. The aim of thesis was to study CBF in demented and non-demented elderly persons with special reference to blood pressure changes. Elderly women with senile dementia of Alzheimer type (SDAT) showed a decrease of CBF in temporoparietal brain regions and in whole white matter. Non-demented elderly women had abnormalities according to SPECT and assessment with vocabulary and visospatial tests. CBF in white matter was correlated positively with systolic blood pressure in SDAT group. It cannot be ruled out, that alterations in blood pressure in SDAT could have a central origin and be the consequence rather than cause of brain changes. Women with SDAT and orthostatic hypotension had lower CBF in frontal and parieto-frontal regions than SDAT patients who had normal orthostatic blood pressure. Orthostatic hypotension could be a risk factor for a frontal brain damage and exacerbate the dementia disorder. Intra-subject comparison of CBF estimated with two tracers in healthy subject revealed higher perfusion in posterior cortex when using 99mTc ECD compared to 99mTc HMPAO. In contrast, CBF in central areas was seen to be more profuse when using 99mTc HMPAO. These differences should be taken into account in clinical routine. In another study, persons with Age-Associated Memory Impairment but without dementia had restricted CBF in temporal and occipital lobes, in thalamus and in frontal white matter. A longitudinal study of 129 men revealed an association between accumulated vascular disease markers as: carotid stenosis, peripheral arterial stenosis and hypertension at the age of 69 and lower CBF 14 years later. These results indicate that there might be a potential for prophylactic activities to prevent cognitive decline and vascular dementia in non-demented 70-80 year old population

AB - The importance of early detection of brain changes during ageing has been recognised. Single photon emission computed tomography (SPECT) is a method used for estimation of cerebral blood flow (CBF) in clinical work and in research. The aim of thesis was to study CBF in demented and non-demented elderly persons with special reference to blood pressure changes. Elderly women with senile dementia of Alzheimer type (SDAT) showed a decrease of CBF in temporoparietal brain regions and in whole white matter. Non-demented elderly women had abnormalities according to SPECT and assessment with vocabulary and visospatial tests. CBF in white matter was correlated positively with systolic blood pressure in SDAT group. It cannot be ruled out, that alterations in blood pressure in SDAT could have a central origin and be the consequence rather than cause of brain changes. Women with SDAT and orthostatic hypotension had lower CBF in frontal and parieto-frontal regions than SDAT patients who had normal orthostatic blood pressure. Orthostatic hypotension could be a risk factor for a frontal brain damage and exacerbate the dementia disorder. Intra-subject comparison of CBF estimated with two tracers in healthy subject revealed higher perfusion in posterior cortex when using 99mTc ECD compared to 99mTc HMPAO. In contrast, CBF in central areas was seen to be more profuse when using 99mTc HMPAO. These differences should be taken into account in clinical routine. In another study, persons with Age-Associated Memory Impairment but without dementia had restricted CBF in temporal and occipital lobes, in thalamus and in frontal white matter. A longitudinal study of 129 men revealed an association between accumulated vascular disease markers as: carotid stenosis, peripheral arterial stenosis and hypertension at the age of 69 and lower CBF 14 years later. These results indicate that there might be a potential for prophylactic activities to prevent cognitive decline and vascular dementia in non-demented 70-80 year old population

KW - Gerontology

KW - Gerontologi

KW - vascular risk factors

KW - carotid ultrasound

KW - peripheral arterial disease

KW - orthostatic hypotension

KW - blood pressure

KW - ageing

KW - SPECT

KW - cerebral blood flow

KW - cognition

KW - Dementia

KW - Alzheimer’s disease

M3 - Doctoral Thesis (compilation)

SN - 91-628-3995-0

PB - Dr Arkadiusz Siennicki-Lantz, Dept of Community Medicine, Malmö University Hospital, S-205 02 Malmö, Sweden,

ER -

Cerebral Blood Flow and Cognition. Clinical studies on Dementia and Cognitive Decline.

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

Fingerprint

Cite this