Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

Ronnie Wirestam; Emelie Lindgren; Danielle van Westen; Karin Markenroth Bloch; Freddy Ståhlberg; Linda Knutsson

doi:10.1111/j.1475-097X.2010.00947.x

Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

Ronnie Wirestam, Emelie Lindgren, Danielle van Westen, Karin Markenroth Bloch, Freddy Ståhlberg, Linda Knutsson

Philips Medical Systems

Research output: Contribution to journal › Article › peer-review

Abstract

Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).

Original language	English
Pages (from-to)	375-379
Journal	Clinical Physiology and Functional Imaging
Volume	30
Issue number	5
DOIs	https://doi.org/10.1111/j.1475-097X.2010.00947.x
Publication status	Published - 2010

Subject classification (UKÄ)

Physiology
Other Physics Topics

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10.1111/j.1475-097X.2010.00947.x

http://www.ncbi.nlm.nih.gov/pubmed/20618360?dopt=Abstract

1 Doctoral Thesis (compilation)

MRI Perfusion Measurements using Magnetic Susceptibility Effects: Calibration Approaches and Contrast Agent Quantification
Lind, E., 2019 Feb, Lund: Naturvetenskapliga fakulteten, Lunds universitet. 181 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
File

1 Finished
1 Active

Optimisation and Validation of Dynamic Susceptibility Contrast MRI
Knutsson, L. (PI) & Wirestam, R. (PI)
1997/01/01 → …
Project: Research
MRI brain perfusion quantification at 3 tesla using arterial spin labeling
Knutsson, L. (PI) & Wirestam, R. (PI)
2006/07/02 → 2017/02/17
Project: Research

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Wirestam, R., Lindgren, E., van Westen, D., Markenroth Bloch, K., Ståhlberg, F., & Knutsson, L. (2010). Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling. Clinical Physiology and Functional Imaging, 30(5), 375-379. https://doi.org/10.1111/j.1475-097X.2010.00947.x

@article{e501f7ca96934bcb9763507309e3ed75,

title = "Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.",

abstract = "Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).",

author = "Ronnie Wirestam and Emelie Lindgren and {van Westen}, Danielle and {Markenroth Bloch}, Karin and Freddy St{\aa}hlberg and Linda Knutsson",

year = "2010",

doi = "10.1111/j.1475-097X.2010.00947.x",

language = "English",

volume = "30",

pages = "375--379",

journal = "Clinical Physiology and Functional Imaging",

issn = "1475-0961",

publisher = "John Wiley & Sons Inc.",

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}

Wirestam, R , Lindgren, E , van Westen, D , Markenroth Bloch, K , Ståhlberg, F & Knutsson, L 2010, 'Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.', Clinical Physiology and Functional Imaging, vol. 30, no. 5, pp. 375-379. https://doi.org/10.1111/j.1475-097X.2010.00947.x

Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling. / Wirestam, Ronnie ; Lindgren, Emelie ; van Westen, Danielle et al.
In: Clinical Physiology and Functional Imaging, Vol. 30, No. 5, 2010, p. 375-379.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

AU - Wirestam, Ronnie

AU - Lindgren, Emelie

AU - van Westen, Danielle

AU - Markenroth Bloch, Karin

AU - Ståhlberg, Freddy

AU - Knutsson, Linda

PY - 2010

Y1 - 2010

N2 - Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).

AB - Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).

U2 - 10.1111/j.1475-097X.2010.00947.x

DO - 10.1111/j.1475-097X.2010.00947.x

M3 - Article

C2 - 20618360

SN - 1475-0961

VL - 30

SP - 375

EP - 379

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 5

ER -

Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

Abstract

Subject classification (UKÄ)

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Research output

MRI Perfusion Measurements using Magnetic Susceptibility Effects: Calibration Approaches and Contrast Agent Quantification

Projects

Optimisation and Validation of Dynamic Susceptibility Contrast MRI

MRI brain perfusion quantification at 3 tesla using arterial spin labeling

Cite this