Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.

Malin Wennström; Sara Hall; Katarina Nägga; Elisabet Londos; Lennart Minthon; Oskar Hansson

doi:10.1186/s13195-015-0145-y

Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.

Malin Wennström, Sara Hall, Katarina Nägga, Elisabet Londos, Lennart Minthon, Oskar Hansson

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Abstract

Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.

Original language	English
Article number	63
Journal	Alzheimer's Research & Therapy
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/s13195-015-0145-y
Publication status	Published - 2015

Subject classification (UKÄ)

Neurology

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http://www.ncbi.nlm.nih.gov/pubmed/26434635?dopt=Abstract

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title = "Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.",

abstract = "Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.",

author = "Malin Wennstr{\"o}m and Sara Hall and Katarina N{\"a}gga and Elisabet Londos and Lennart Minthon and Oskar Hansson",

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T1 - Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.

AU - Wennström, Malin

AU - Hall, Sara

AU - Nägga, Katarina

AU - Londos, Elisabet

AU - Minthon, Lennart

AU - Hansson, Oskar

PY - 2015

Y1 - 2015

N2 - Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.

AB - Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.

U2 - 10.1186/s13195-015-0145-y

DO - 10.1186/s13195-015-0145-y

M3 - Article

C2 - 26434635

SN - 1758-9193

VL - 7

JO - Alzheimer's Research & Therapy

JF - Alzheimer's Research & Therapy

IS - 1

M1 - 63

ER -

Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.

Abstract

Subject classification (UKÄ)

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