Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.

Hlin Kvartsberg; Flora H Duits; Martin Ingelsson; Niels Andreasen; Annika Öhrfelt; Kerstin Andersson; Gunnar Brinkmalm; Lars Lannfelt; Lennart Minthon; Oskar Hansson; Ulf Andreasson; Charlotte E Teunissen; Philip Scheltens; Wiesje M Van der Flier; Henrik Zetterberg; Erik Portelius; Kaj Blennow

doi:10.1016/j.jalz.2014.10.009

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.

Hlin Kvartsberg, Flora H Duits, Martin Ingelsson, Niels Andreasen, Annika Öhrfelt, Kerstin Andersson, Gunnar Brinkmalm, Lars Lannfelt, Lennart Minthon, Oskar Hansson, Ulf Andreasson, Charlotte E Teunissen, Philip Scheltens, Wiesje M Van der Flier, Henrik Zetterberg, Erik Portelius, Kaj Blennow

Research output: Contribution to journal › Article › peer-review

Abstract

Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment. Consequently, synaptic biomarkers may be valuable tools for both early diagnosis and disease stage. Neurogranin (Ng) is a postsynaptic protein involved in memory consolidation.

Original language	English
Pages (from-to)	1180-1190
Journal	Alzheimer's & Dementia
Volume	11
Issue number	10
DOIs	https://doi.org/10.1016/j.jalz.2014.10.009
Publication status	Published - 2015

Subject classification (UKÄ)

Neurology

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10.1016/j.jalz.2014.10.009

http://www.ncbi.nlm.nih.gov/pubmed/25533203?dopt=Abstract

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Kvartsberg, H., Duits, F. H., Ingelsson, M., Andreasen, N., Öhrfelt, A., Andersson, K., Brinkmalm, G., Lannfelt, L., Minthon, L., Hansson, O., Andreasson, U., Teunissen, C. E., Scheltens, P., Van der Flier, W. M., Zetterberg, H., Portelius, E., & Blennow, K. (2015). Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease. Alzheimer's & Dementia, 11(10), 1180-1190. https://doi.org/10.1016/j.jalz.2014.10.009

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title = "Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.",

abstract = "Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment. Consequently, synaptic biomarkers may be valuable tools for both early diagnosis and disease stage. Neurogranin (Ng) is a postsynaptic protein involved in memory consolidation.",

author = "Hlin Kvartsberg and Duits, {Flora H} and Martin Ingelsson and Niels Andreasen and Annika {\"O}hrfelt and Kerstin Andersson and Gunnar Brinkmalm and Lars Lannfelt and Lennart Minthon and Oskar Hansson and Ulf Andreasson and Teunissen, {Charlotte E} and Philip Scheltens and {Van der Flier}, {Wiesje M} and Henrik Zetterberg and Erik Portelius and Kaj Blennow",

year = "2015",

doi = "10.1016/j.jalz.2014.10.009",

language = "English",

volume = "11",

pages = "1180--1190",

journal = "Alzheimer's & Dementia",

issn = "1552-5279",

publisher = "Wiley",

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Kvartsberg, H, Duits, FH, Ingelsson, M, Andreasen, N, Öhrfelt, A, Andersson, K, Brinkmalm, G, Lannfelt, L, Minthon, L, Hansson, O, Andreasson, U, Teunissen, CE, Scheltens, P, Van der Flier, WM, Zetterberg, H, Portelius, E & Blennow, K 2015, 'Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.', Alzheimer's & Dementia, vol. 11, no. 10, pp. 1180-1190. https://doi.org/10.1016/j.jalz.2014.10.009

TY - JOUR

T1 - Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.

AU - Kvartsberg, Hlin

AU - Duits, Flora H

AU - Ingelsson, Martin

AU - Andreasen, Niels

AU - Öhrfelt, Annika

AU - Andersson, Kerstin

AU - Brinkmalm, Gunnar

AU - Lannfelt, Lars

AU - Minthon, Lennart

AU - Hansson, Oskar

AU - Andreasson, Ulf

AU - Teunissen, Charlotte E

AU - Scheltens, Philip

AU - Van der Flier, Wiesje M

AU - Zetterberg, Henrik

AU - Portelius, Erik

AU - Blennow, Kaj

PY - 2015

Y1 - 2015

N2 - Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment. Consequently, synaptic biomarkers may be valuable tools for both early diagnosis and disease stage. Neurogranin (Ng) is a postsynaptic protein involved in memory consolidation.

AB - Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment. Consequently, synaptic biomarkers may be valuable tools for both early diagnosis and disease stage. Neurogranin (Ng) is a postsynaptic protein involved in memory consolidation.

U2 - 10.1016/j.jalz.2014.10.009

DO - 10.1016/j.jalz.2014.10.009

M3 - Article

SN - 1552-5279

VL - 11

SP - 1180

EP - 1190

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 10

ER -

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.

Abstract

Subject classification (UKÄ)

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