Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation

Ronnie Wirestam; Christian Engvall; Erik Ryding; Stig Holtas; Freddy Stahlberg; Peter Reinstrup

Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation

Ronnie Wirestam, Christian Engvall, Erik Ryding, Stig Holtas, Freddy Stahlberg, Peter Reinstrup

Medical Radiation Physics, Lund

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.

Original language	English
Title of host publication	2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11
Publisher	IEEE - Institute of Electrical and Electronics Engineers Inc.
Pages	2291-2294
Publication status	Published - 2009
Event	3rd International Conference on Bioinformatics and Biomedical Engineering - Beijing, PEOPLES R CHINA Duration: 2009 Jun 11 → 2009 Jun 16

Conference

Conference	3rd International Conference on Bioinformatics and Biomedical Engineering
Period	2009/06/11 → 2009/06/16

Subject classification (UKÄ)

Radiology and Medical Imaging

Free keywords

magnetic resonance imaging
perfusion
cerebral blood flow
mean
transit time
hypocapnia

Cite this

Wirestam, R., Engvall, C., Ryding, E., Holtas, S., Stahlberg, F., & Reinstrup, P. (2009). Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation. In 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11 (pp. 2291-2294). IEEE - Institute of Electrical and Electronics Engineers Inc..

Wirestam, Ronnie ; Engvall, Christian ; Ryding, Erik et al. / Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation. 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11. IEEE - Institute of Electrical and Electronics Engineers Inc., 2009. pp. 2291-2294

@inproceedings{7f3c1aa71a65469891466acba2c16b18,

title = "Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation",

abstract = "Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29\%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13\%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.",

keywords = "magnetic resonance imaging, perfusion, cerebral blood flow, mean, transit time, hypocapnia",

author = "Ronnie Wirestam and Christian Engvall and Erik Ryding and Stig Holtas and Freddy Stahlberg and Peter Reinstrup",

year = "2009",

language = "English",

pages = "2291--2294",

booktitle = "2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11",

publisher = "IEEE - Institute of Electrical and Electronics Engineers Inc.",

address = "United States",

note = "3rd International Conference on Bioinformatics and Biomedical Engineering ; Conference date: 11-06-2009 Through 16-06-2009",

}

Wirestam, R, Engvall, C, Ryding, E, Holtas, S, Stahlberg, F & Reinstrup, P 2009, Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation. in 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11. IEEE - Institute of Electrical and Electronics Engineers Inc., pp. 2291-2294, 3rd International Conference on Bioinformatics and Biomedical Engineering, 2009/06/11.

Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation. / Wirestam, Ronnie; Engvall, Christian; Ryding, Erik et al.
2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11. IEEE - Institute of Electrical and Electronics Engineers Inc., 2009. p. 2291-2294.

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

TY - GEN

T1 - Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation

AU - Wirestam, Ronnie

AU - Engvall, Christian

AU - Ryding, Erik

AU - Holtas, Stig

AU - Stahlberg, Freddy

AU - Reinstrup, Peter

PY - 2009

Y1 - 2009

N2 - Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.

AB - Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.

KW - magnetic resonance imaging

KW - perfusion

KW - cerebral blood flow

KW - mean

KW - transit time

KW - hypocapnia

UR - https://www.scopus.com/pages/publications/72749090604

M3 - Paper in conference proceeding

SP - 2291

EP - 2294

BT - 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11

PB - IEEE - Institute of Electrical and Electronics Engineers Inc.

T2 - 3rd International Conference on Bioinformatics and Biomedical Engineering

Y2 - 11 June 2009 through 16 June 2009

ER -

Wirestam R, Engvall C, Ryding E, Holtas S, Stahlberg F, Reinstrup P. Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation. In 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11. IEEE - Institute of Electrical and Electronics Engineers Inc. 2009. p. 2291-2294

Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation

Abstract

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Subject classification (UKÄ)

Free keywords

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