Research output per year
Research output per year
Michael Karlsson, Johannes K. Ehinger, Sarah Piel, Fredrik Sjövall, Johanna Henriksnäs, Urban Höglund, Magnus J. Hansson, Eskil Elmér
Research output: Contribution to journal › Article › peer-review
Metabolic crisis is a clinical condition primarily affecting patients with inherent mitochondrial dysfunction in situations of augmented energy demand. To model this, ten pigs received an infusion of rotenone, a mitochondrial complex I inhibitor, or vehicle. Clinical parameters, blood gases, continuous indirect calorimetry, in vivo muscle oxygen tension, ex vivo mitochondrial respiration and metabolomics were assessed. Rotenone induced a progressive increase in blood lactate which was paralleled by an increase in oxygen tension in venous blood and skeletal muscle. There was an initial decrease in whole body oxygen utilization, and there was a trend towards inhibited mitochondrial respiration in platelets. While levels of succinate were decreased, other intermediates of glycolysis and the TCA cycle were increased. This model may be suited for evaluating pharmaceutical interventions aimed at counteracting metabolic changes due to complex I dysfunction.
Original language | English |
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Pages (from-to) | 56-62 |
Number of pages | 7 |
Journal | Mitochondrion |
Volume | 31 |
DOIs | |
Publication status | Published - 2016 Nov 1 |
Research output: Thesis › Doctoral Thesis (compilation)
Research output: Thesis › Doctoral Thesis (compilation)
Elmer, E. (PI), Ehinger, J. (CoPI), Hansson, M. (Researcher), Åsander Frostner, E. (Research student), Chamkha, I. (Researcher), Karlsson, M. (Research student), Marelsson, S. (Research student), Sjövall, F. (Researcher) & Westerlund, E. (Researcher)
2013/04/01 → …
Project: Research
Elmer, E. (PI), Hansson, M. (Researcher), Piel, S. (Researcher), Ehinger, J. (Researcher), Karlsson, M. (Researcher), Chamkha, I. (Researcher), Westerlund, E. (Researcher), Åsander Frostner, E. (Research engineer), Sjövall, F. (Researcher) & Marelsson, S. (Research student)
Crafoord Foundation, Linnéa och Josef Carlssons stiftelse
2012/05/01 → …
Project: Research