Changes in insulin secretion from pancreatic islets following treatment with neuraminidase

H. J. Hahn, B. Hellman, A. Lernmark, I. B. Taljedal

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of pancreatic islets from ob/ob-mice with bacterial neuraminidase (0.8 to 40 mU/ml) resulted in a significant decrease of the sialic acid content and of the secretory response to glucose. The inhibitory effect on the glucose stimulated insulin release was reproduced with different batches of neuraminidase from Clostridium perfringens and Vibrio cholera. Treatment with neuraminidase affected neither the insulin content of the islets nor the potentiating effect of theophylline in the presence of 20 mM glucose. The results suggest that sialic acid plays a role in the mechanism of insulin release and that the inhibitory effect of sialic acid depletion is overcome by theophylline. (30 references.)

Translated title of the contributionChanges in insulin secretion from pancreatic islets following treatment with neuraminidase
Original languageGerman
Pages (from-to)375-383
Number of pages9
JournalActa Biologica et Medica Germanica
Volume32
Issue number4
Publication statusPublished - 1974 Jan 1
Externally publishedYes

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