Chaotic electrical activity of living beta-cells in the mouse pancreatic islet

Takahiro Kanno, Takaya Miyano, Isao Tokuda, Juris Galvanovskis, Makoto Wakui

    Research output: Contribution to journalArticlepeer-review

    Abstract

    To test for chaotic dynamics of the insulin producing beta-cell and explore its biological role, we observed the action potentials with the perforated patch clamp technique, for isolated cells as well as for intact cells of the mouse pancreatic islet. The time series obtained were analyzed using nonlinear diagnostic algorithms associated with the surrogate method. The isolated cells exhibited short-term predictability and visible determinism, in the steady state response to 10 mM glucose, while the intact cells did not. In the latter case, determinism became visible after the application of a gap junction inhibitor. This tendency was enhanced by the stimulation with tolbutamide. Our observations suggest that, thanks to the integration of individual chaotic dynamics via gap junction coupling, the beta-cells will lose memory of fluctuations occurring at any instant in their electrical activity more rapidly with time. This is likely to contribute to the functional stability of the islet against uncertain perturbations. (c) 2006 Elsevier B.V All rights reserved.
    Original languageEnglish
    Pages (from-to)107-116
    JournalPhysica D: Nonlinear Phenomena
    Volume226
    Issue number2
    DOIs
    Publication statusPublished - 2007

    Subject classification (UKÄ)

    • Endocrinology and Diabetes

    Free keywords

    • gap junction
    • pancreatic beta-cell
    • time series analysis
    • synchronization
    • chaos

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