Chapter 40 - Lymphocyte Trafficking to Mucosal Tissues

Zamaneh Mikhak, William W. Agace, Andrew D. Luster

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


Lymphocytes are the key cells of the adaptive immune system that provide antigen-specific responses tailored to the context of antigen exposure. Through cytokine release and antibody production, lymphocytes orchestrate and amplify the recruitment and function of other immune cells and contribute to host defense against invading pathogens and the pathogenesis of many inflammatory diseases. Lymphocyte function is critically dependent on their ability to traffic into the correct anatomic locations at the appropriate times. This process is highly regulated and requires that lymphocytes interact with various homing molecules and respond to tightly regulated navigational cues.

Original languageEnglish
Title of host publicationMucosal Immunology
Subtitle of host publicationFourth Edition
ISBN (Electronic)9780124159754
ISBN (Print)9780124158474
Publication statusPublished - 2015 Apr 1

Subject classification (UKÄ)

  • Immunology in the medical area

Free keywords

  • Cell migration
  • Cell trafficking
  • Chemoattractants
  • Chemokines
  • Chemotaxis
  • Gut
  • Homing
  • Imprinting
  • Integrins
  • Lung
  • Mucosal immunology
  • T cells


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