Abstract
The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5-HT and alpha-methyl-5-HT were antagonized by ketanserin, as well as methiothepin. The contractile effect of sumatriptan was antagonized by methiothepin but not by ketanserin. The 5-HT3 receptor antagonist, MDL 72222, did not affect the contraction by any of the agonists, including 2-methyl-5-HT. It is concluded that the 5-HT-induced contraction in the circular smooth muscle of the human umbilical artery seems to be mediated by a mixed population of 5-HT1-like receptors and 5-HT2 receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 102-107 |
| Journal | Gynecologic and Obstetric Investigation |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1999 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Research Unit for Urogynaecology and Reproductive Pharmacology (013242710), Division of Infection Medicine (BMC) (013024020), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Preventive Paediatrics (013243030)
Subject classification (UKÄ)
- Infectious Medicine
- Obstetrics, Gynecology and Reproductive Medicine
- Pediatrics
- Clinical Medicine
Free keywords
- Vascular smooth muscle
- Umbilical artery
- Serotonin
- human
- Receptor
