Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

Lotta Andersson, Berengere Valtat, Annika Bagge, Vladimir Sharoyko, David Nicholls, Philippe Ravassard, Raphael Scharfmann, Peter Spégel, Hindrik Mulder

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Abstract

Studies on beta cell metabolism are often conducted in rodent beta cell lines due to the lack of stable human beta cell lines. Recently, a human cell line, EndoC-βH1, was generated. Here we investigate stimulus-secretion coupling in this cell line, and compare it with that in the rat beta cell line, INS-1 832/13, and human islets.
Original languageEnglish
Article numbere0120879
JournalPLoS ONE
Volume10
Issue number3
DOIs
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Endocrinology and Diabetes

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