Characterizing motor and non-motor aspects of early-morning off periods in Parkinson's disease: An international multicenter study.

A Rizos, P Martinez-Martin, Per Odin, A Antonini, B Kessel, T Klemencic Kozul, A Todorova, A Douiri, A Martin, F Stocchi, E Dietrichs, K Ray Chaudhuri

Research output: Contribution to journalArticlepeer-review

41 Citations (SciVal)

Abstract

The characteristic off periods that develop over time in subjects with Parkinson's disease (PD) on chronic levodopa therapy are usually considered to be motor complications but more recently the important contribution of non-motor off and non-motor fluctuations has also been acknowledged. Early-morning off (EMO) periods in PD patients are known to be a cause of significant disability, in addition to having a negative impact on quality of life. Yet EMOs are poorly defined, particularly in relation to non-motor symptoms (NMS).
Original languageEnglish
Pages (from-to)1231-1235
JournalParkinsonism & Related Disorders
Volume20
Issue number11
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Neurology

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