Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.

Russell A Hermansen; Brian K Mannakee; Wolfgang Knecht; David A Liberles; Ryan N Gutenkunst

doi:10.1186/s12862-015-0515-x

Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.

Russell A Hermansen, Brian K Mannakee, Wolfgang Knecht, David A Liberles, Ryan N Gutenkunst

Research output: Contribution to journal › Article › peer-review

Abstract

Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.

Original language	English
Article number	232
Journal	BMC Evolutionary Biology
Volume	15
DOIs	https://doi.org/10.1186/s12862-015-0515-x
Publication status	Published - 2015

Subject classification (UKÄ)

Cell Biology

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10.1186/s12862-015-0515-x

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title = "Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.",

abstract = "Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.",

author = "Hermansen, {Russell A} and Mannakee, {Brian K} and Wolfgang Knecht and Liberles, {David A} and Gutenkunst, {Ryan N}",

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doi = "10.1186/s12862-015-0515-x",

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publisher = "BioMed Central (BMC)",

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AU - Hermansen, Russell A

AU - Mannakee, Brian K

AU - Knecht, Wolfgang

AU - Liberles, David A

AU - Gutenkunst, Ryan N

PY - 2015

Y1 - 2015

N2 - Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.

AB - Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.

U2 - 10.1186/s12862-015-0515-x

DO - 10.1186/s12862-015-0515-x

M3 - Article

C2 - 26511837

SN - 1471-2148

VL - 15

JO - BMC Evolutionary Biology

JF - BMC Evolutionary Biology

M1 - 232

ER -

Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.

Abstract

Subject classification (UKÄ)

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