Chemoenzymatic Synthesis of Glycopeptides Bearing Galactose-Xylose Disaccharide from the Proteoglycan Linkage Region

Jia Gao, Po Han Lin, Setare Tahmasebi Nick, Junfeng Huang, Emil Tykesson, Ulf Ellervik, Lingjun Li, Xuefei Huang

Research output: Contribution to journalArticlepeer-review

2 Citations (SciVal)

Abstract

Proteoglycans have important biological activities. To improve the overall synthetic efficiency, a new chemoenzymatic route has been established for the proteoglycan linkage region bearing a galactose-xylose disaccharide. The xylosylated glycopeptides were synthesized via solid phase synthesis, which was followed by the addition of the galactose unit by the galactosyl transferase β4GalT7. This work leads to a better understanding of the acceptor preference of β4GalT7 and opens the door for expeditious synthesis of the proteoglycan linkage region.

Original languageEnglish
Pages (from-to)1738–1741
JournalOrganic Letters
Volume23
Issue number5
DOIs
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Organic Chemistry

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