Childhood malignancy and maternal diabetes or other auto-immune disease during pregnancy.

Lena Westbom, Anders E Åberg, Bengt Källén

Research output: Contribution to journalArticlepeer-review


Among 4380 children born in 1987-1997 of women with a diagnosis of diabetes and alive at the age of one, 10 were registered in the Swedish Cancer Registry before the end of 1998. The odds ratio for having a childhood cancer after maternal diabetes, stratified for year of birth, maternal age, parity, multiple birth, and 500 g birth weight class was 2.25 (95%CI 1.22-4.15). Among 5842 children born during the period 1973-1997 whose mothers had other auto-immune diseases (SLE, rheumatoid arthritis, Crohn, ulcerous colitis, multiple sclerosis or thyroiditis), the number of observed childhood cancers (9) was close to that expected (8.5). Maternal diabetes but not other auto-immune diseases may be a risk factor for childhood cancer.
Original languageEnglish
Pages (from-to)1078-1080
JournalBritish Journal of Cancer
Issue number7
Publication statusPublished - 2002

Subject classification (UKÄ)

  • Cancer and Oncology


  • Child Welfare
  • Child
  • Preschool
  • Diabetes Mellitus
  • Insulin-Dependent : complications
  • Female
  • Infant
  • Human
  • Newborn
  • Male
  • Neoplasms : etiology
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Autoimmune Diseases : complications


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