Chromatin, epigenetics and stem cells

Tim C Roloff, Ulrike Nuber

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    Epigenetics is a term that has changed its meaning with the increasing biological knowledge on developmental processes. However, its current application to stem cell biology is often imprecise and is conceptually problematic. This article addresses two different subjects, the definition of epigenetics and chromatin states of stem and differentiated cells. We describe mechanisms that regulate chromatin changes and provide an overview of chromatin states of stem and differentiated cells. Moreover, a modification of the current epigenetics definition is proposed that is not restricted by the heritability of gene expression throughout cell divisions and excludes translational gene expression control.
    Original languageEnglish
    Pages (from-to)123-135
    JournalEuropean Journal of Cell Biology
    Volume84
    Issue number2-3
    DOIs
    Publication statusPublished - 2005

    Subject classification (UKÄ)

    • Cell and Molecular Biology

    Keywords

    • Stem cells
    • Epigenetics
    • Chromatin
    • Histone modification
    • DNA methylation
    • Gene expression

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