Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families

C Petersson, N Pandis, F Mertens, A Adeyinka, C Ingvar, A Ringberg, I Idvall, L Bondeson, A Borg, Håkan Olsson, U Kristoffersson, F Mitelman

Research output: Contribution to journalArticlepeer-review


Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalGenes, Chromosomes and Cancer
Issue number3
Publication statusPublished - 1996 Jul

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Surgery Research Unit (013242220), Division of Clinical Genetics (013022003), Cancer Epidemiology (013007100), Oncology, MV (013035000), Pathology (Malmö) (013031000), Pathology, (Lund) (013030000), Surgery (Lund) (013009000)

Subject classification (UKÄ)

  • Cancer and Oncology
  • Medical Genetics

Free keywords

  • Adult
  • Breast Neoplasms
  • Cells, Cultured
  • Chromosome Aberrations
  • Female
  • Genetic Diseases, Inborn
  • Humans
  • Hyperplasia
  • Karyotyping
  • Mastectomy
  • Middle Aged
  • Precancerous Conditions
  • Risk Factors
  • Case Reports
  • Journal Article
  • Research Support, Non-U.S. Gov't


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