Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families

C Petersson; N Pandis; F Mertens; A Adeyinka; C Ingvar; A Ringberg; I Idvall; L Bondeson; A Borg; Håkan Olsson; U Kristoffersson; F Mitelman

doi:10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V

Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families

C Petersson, N Pandis, F Mertens, A Adeyinka, C Ingvar, A Ringberg, I Idvall, L Bondeson, A Borg, Håkan Olsson, U Kristoffersson, F Mitelman

Lund University

Research output: Contribution to journal › Article › peer-review

Abstract

Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.

Original language	English
Pages (from-to)	185-188
Number of pages	4
Journal	Genes, Chromosomes and Cancer
Volume	16
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V
Publication status	Published - 1996 Jul

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Surgery Research Unit (013242220), Division of Clinical Genetics (013022003), Cancer Epidemiology (013007100), Oncology, MV (013035000), Pathology (Malmö) (013031000), Pathology, (Lund) (013030000), Surgery (Lund) (013009000)

Subject classification (UKÄ)

Cancer and Oncology
Medical Genetics

Free keywords

Adult
Breast Neoplasms
Cells, Cultured
Chromosome Aberrations
Female
Genetic Diseases, Inborn
Humans
Hyperplasia
Karyotyping
Mastectomy
Middle Aged
Precancerous Conditions
Risk Factors
Case Reports
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V

Cite this

Petersson, C., Pandis, N., Mertens, F., Adeyinka, A., Ingvar, C., Ringberg, A., Idvall, I., Bondeson, L., Borg, A., Olsson, H., Kristoffersson, U., & Mitelman, F. (1996). Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families. Genes, Chromosomes and Cancer, 16(3), 185-188. https://doi.org/10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V

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title = "Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families",

abstract = "Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.",

keywords = "Adult, Breast Neoplasms, Cells, Cultured, Chromosome Aberrations, Female, Genetic Diseases, Inborn, Humans, Hyperplasia, Karyotyping, Mastectomy, Middle Aged, Precancerous Conditions, Risk Factors, Case Reports, Journal Article, Research Support, Non-U.S. Gov't",

author = "C Petersson and N Pandis and F Mertens and A Adeyinka and C Ingvar and A Ringberg and I Idvall and L Bondeson and A Borg and H{\aa}kan Olsson and U Kristoffersson and F Mitelman",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Division of Clinical Genetics (013022003), Cancer Epidemiology (013007100), Oncology, MV (013035000), Pathology (Malm{\"o}) (013031000), Pathology, (Lund) (013030000), Surgery (Lund) (013009000)",

year = "1996",

month = jul,

doi = "10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V",

language = "English",

volume = "16",

pages = "185--188",

journal = "Genes, Chromosomes and Cancer",

issn = "1045-2257",

publisher = "Wiley-Liss Inc.",

number = "3",

}

Petersson, C, Pandis, N, Mertens, F, Adeyinka, A, Ingvar, C , Ringberg, A, Idvall, I, Bondeson, L, Borg, A, Olsson, H, Kristoffersson, U & Mitelman, F 1996, 'Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families', Genes, Chromosomes and Cancer, vol. 16, no. 3, pp. 185-188. https://doi.org/10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V

TY - JOUR

T1 - Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families

AU - Petersson, C

AU - Pandis, N

AU - Mertens, F

AU - Adeyinka, A

AU - Ingvar, C

AU - Ringberg, A

AU - Idvall, I

AU - Bondeson, L

AU - Borg, A

AU - Olsson, Håkan

AU - Kristoffersson, U

AU - Mitelman, F

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Division of Clinical Genetics (013022003), Cancer Epidemiology (013007100), Oncology, MV (013035000), Pathology (Malmö) (013031000), Pathology, (Lund) (013030000), Surgery (Lund) (013009000)

PY - 1996/7

Y1 - 1996/7

N2 - Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.

AB - Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.

KW - Adult

KW - Breast Neoplasms

KW - Cells, Cultured

KW - Chromosome Aberrations

KW - Female

KW - Genetic Diseases, Inborn

KW - Humans

KW - Hyperplasia

KW - Karyotyping

KW - Mastectomy

KW - Middle Aged

KW - Precancerous Conditions

KW - Risk Factors

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V

DO - 10.1002/(SICI)1098-2264(199607)16:3<185::AID-GCC5>3.0.CO;2-V

M3 - Article

C2 - 8814451

SN - 1045-2257

VL - 16

SP - 185

EP - 188

JO - Genes, Chromosomes and Cancer

JF - Genes, Chromosomes and Cancer

IS - 3

ER -

Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Fingerprint

Cite this