Chronic kidney disease after heart transplantation: a single-centre retrospective study at skåne university hospital in lund 1988-2010.

Carl Söderlund, Eveline Löfdahl, Johan Nilsson, Öyvind Reitan, Thomas Higgins, Göran Rådegran

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Abstract

We aimed to study the incidence, predictors, and outcome of chronic kidney disease (CKD) after heart transplantation (HT). All our HT patients 1988-2010 were considered for inclusion. Of these, 134 came for annual follow-ups including evaluation of glomerular filtration rate (GFR) using iohexol clearance measurements, and the CKD-EPI (adults) or Schwartz (children) formulae. Median GFR (Q1-Q3)(mL/min/1.73m(2) ) declined from 67.0 (50.0-82.0) during transplant assessment (TA), to 56.0 (45.0-69.0) at year 1, 53.0 (41.0-68.0) at year 5 and 44.5 (25.0-57.3) at year 10. The cumulative incidence of CKD ≥ stage 4 was 25% at 5 years and 41% at 10 years after transplantation. Proteinuria the first year post-HT was the only predictor related (p<0.05) to a higher rate of GFR decline (HR 5.15, 95% CI 1.23-21.55). GFR ≥60 as compared to <60 before HT, or a first year GFR decline <30% as compared to >30%, was moreover associated (p<0.05) with a lower risk of death (HR 0.30, 95% CI 0.12-0.76 and HR 0.35, 95% CI 0.13-0.90, respectively). Notably, the CKD-EPI and Schwartz formulae overestimated GFR by 28±29% and 26±33%, respectively. In conclusion, CKD in HT patients is common and associated with worse outcome. To avoid diagnostic delay, GFR estimating equation's validity in HT patients needs further study. This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)529-539
JournalTransplant international : official journal of the European Society for Organ Transplantation
Volume29
Issue number5
Early online date2015 Nov 4
DOIs
Publication statusPublished - 2016

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

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