Abstract
Circadian variations of hexobarbital oxidation rate in rat liver and the relationship to serum corticosterone levels were determined in 324 animals subjected to different lighting regimen and feeding schedules.--Rats maintained under standard light/dark conditions and with free access to food showed a significant circadian hexobarbital oxidase rhythmicity. Inversion of the light/dark cycle and time feeding was followed by significant changes of the 24-h means of hexobarbital oxidation rate as well as of the shape and phasing of the circadian pattern. The animals' response to the experimentally altered environmental conditions did not reveal a predictable relationship between the shape and phasing of the rhythmic patterns of liver hexobarbital oxidase activity and of corticosterone levels in blood serum; the rats subjected to timed feeding showed decreased levels of corticosterone whereas the hexobarbital oxidation rate of the liver was increased.
| Original language | English |
|---|---|
| Pages (from-to) | 199-204 |
| Journal | Archives of Toxicology |
| Volume | 48 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 1981 |
| Externally published | Yes |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
Subject classification (UKÄ)
- Pharmacology and Toxicology
Free keywords
- Hexobarbital oxidation
- Corticosterone
- Circadianrhythm
- Rat liver