TY - JOUR
T1 - Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress
AU - Chen, Yihong
AU - Shen, Junyan
AU - Hultgårdh Nilsson, Anna
AU - Goncalves, Isabel
AU - Edsfeldt, Andreas
AU - Engström, Gunnar
AU - Zaigham, Suneela
AU - Melander, Olle
AU - Orho-Melander, Marju
AU - Rauch, Uwe
AU - Venuraju, Shreenidhi M.
AU - Lahiri, Avijit
AU - Liang, Chun
AU - Jan, Nilsson
PY - 2022
Y1 - 2022
N2 - Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.
AB - Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.
U2 - 10.1016/j.jacbts.2022.03.013
DO - 10.1016/j.jacbts.2022.03.013
M3 - Article
C2 - 36061342
SN - 2452-302X
VL - 7
SP - 747
EP - 762
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 8
ER -