Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Marcelo Soto Thompson; Ann Johansson; Thomas Johansson; Stefan Andersson-Engels; Sune Svanberg; Niels Bendsöe; Katarina Svanberg

Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Marcelo Soto Thompson, Ann Johansson, Thomas Johansson, Stefan Andersson-Engels, Sune Svanberg, Niels Bendsöe, Katarina Svanberg

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Abstract

A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photo-bleaching, and a relatively constant global tissue oxygen saturation level during the treatment.

Original language	English
Pages (from-to)	4023-4031
Journal	Applied Optics
Volume	44
Issue number	19
Publication status	Published - 2005

Subject classification (UKÄ)

Cancer and Oncology
Dermatology and Venereal Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Thompson2005

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16004049&dopt=AbstractPlus

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title = "Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements",

abstract = "A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photo-bleaching, and a relatively constant global tissue oxygen saturation level during the treatment.",

author = "\{Soto Thompson\}, Marcelo and Ann Johansson and Thomas Johansson and Stefan Andersson-Engels and Sune Svanberg and Niels Bends{\"o}e and Katarina Svanberg",

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language = "English",

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journal = "Applied Optics",

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T1 - Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

AU - Soto Thompson, Marcelo

AU - Johansson, Ann

AU - Johansson, Thomas

AU - Andersson-Engels, Stefan

AU - Svanberg, Sune

AU - Bendsöe, Niels

AU - Svanberg, Katarina

PY - 2005

Y1 - 2005

N2 - A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photo-bleaching, and a relatively constant global tissue oxygen saturation level during the treatment.

AB - A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photo-bleaching, and a relatively constant global tissue oxygen saturation level during the treatment.

UR - https://www.scopus.com/pages/publications/22144474393

M3 - Article

SN - 2155-3165

VL - 44

SP - 4023

EP - 4031

JO - Applied Optics

JF - Applied Optics

IS - 19

ER -

Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Abstract

Subject classification (UKÄ)

UN SDGs

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