Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.

Britta Halvarsson, Harald Anderson, Katarina Bartuma, Gudrun Lindmark, Mef Nilbert

Research output: Contribution to journalArticlepeer-review

Abstract

Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers.
Original languageEnglish
Pages (from-to)238-244
JournalAmerican Journal of Clinical Pathology
Volume129
Issue number2
DOIs
Publication statusPublished - 2008

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Oncology, MV (013035000), Cancer Epidemiology (013007100), Pathology, (Lund) (013030000), Surgery Research Unit (013242220)

Subject classification (UKÄ)

  • Cancer and Oncology

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